Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues [PDF]
Pharmacology Research & Perspectives, 2023 UDP‐glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that play important roles in the detoxification of endogenous and exogenous substrates.
Lucas Zhou +3 more
doaj +3 more sources
Age-Dependent Hepatic UDP-Glucuronosyltransferase Gene Expression and Activity in Children
Frontiers in Pharmacology, 2016 UDP-glucuronosyltransferases (UGTs) are important phase II drug metabolism enzymes. The aim of this study was to explore the relationship between age and changes in mRNA expression and activity of major human hepatic UGTs, as well as to understand the ...
Huma Mehboob, Wanqing Liu
exaly +4 more sources
Bilirubin metabolism and UDP‐glucuronosyltransferase 1A1 variants in Asians: Pathogenic implications and therapeutic response [PDF]
Kaohsiung Journal of Medical Sciences, 2022 In the Asian general population, at least six single‐nucleotide variants (SNVs) in the UDP‐glucuronosyltransferase (UGT) 1A1 gene have been identified: −3279T>G, −53A(TA)6TAA>A(TA)7TAA, 211G>A, 686C>A, 1091C>T, and 1456T>G.
May‐Jen Huang +2 more
doaj +2 more sources
Machine learning and structure-based modeling for the prediction of UDP-glucuronosyltransferase inhibition [PDF]
iScience, 2022 Summary: UDP-glucuronosyltransferases (UGTs) are responsible for 35% of the phase II drug metabolism. In this study, we focused on UGT1A1, which is a key UGT isoform.
Balint Dudas +4 more
doaj +2 more sources
Effect of UDP‐glucuronosyltransferase 1A1 activity on risk for developing Gilbert's syndrome [PDF]
Kaohsiung Journal of Medical Sciences, 2019 Variations at the six nucleotides −3279 (T > G), −53 (A[TA]6TAA > A[TA]7TAA), 211 (G > A), 686 (C > A), 1091 (C > T), and 1456 (T > G) in the UDP‐glucuronosyltransferase 1A1 (UGT1A1) gene were determined in 178 Taiwanese patients with Gilbert's syndrome ...
May‐Jen Huang +5 more
doaj +2 more sources
Duplication, Loss, and Evolutionary Features of Specific UDP-Glucuronosyltransferase Genes in Carnivora (Mammalia, Laurasiatheria) [PDF]
Animals, 2022 UDP-glucuronosyltransferases (UGTs) are one of the most important enzymes for xenobiotic metabolism or detoxification. Through duplication and loss of genes, mammals evolved the species-specific variety of UGT isoforms. Among mammals, Carnivora is one of
Mitsuki Kondo +4 more
doaj +2 more sources
Integrate thermostabilized fusion protein apocytochrome b562RIL and N-glycosylation mutations: A novel approach to heterologous expression of human UDP-glucuronosyltransferase (UGT) 2B7 [PDF]
Frontiers in Pharmacology, 2022 Human UDP-glucuronosyltransferase (UGT) 2B7 is a crucial phase II metabolic enzyme that transfers glucuronic acid from UDP-glucuronic acid (UDPGA) to endobiotic and xenobiotic substrates.
Jia Xue +3 more
doaj +2 more sources
Inhibitory Effect of Sauchinone on UDP-Glucuronosyltransferase (UGT) 2B7 Activity [PDF]
Molecules, 2018 Herb–drug interaction (HDI) limits clinical application of herbs and drugs, and inhibition of herbs towards uridine diphosphate (UDP)-glucuronosyltransferases (UGTs) has gained attention as one of the important reasons to cause HDIs.
Byoung Hoon You +2 more
doaj +2 more sources
UGTformer: a pretrained graph transformer model for predicting UDP-glucuronosyltransferase-mediated drug metabolism [PDF]
Journal of CheminformaticsUDP-glucuronosyltransferases (UGTs) play a critical role in drug metabolism by catalyzing the glucuronidation of structurally diverse compounds. However, accurately predicting UGT-mediated sites of metabolism (SOMs) remains a challenge due to the limited
Meiling Zhan +7 more
doaj +2 more sources
Identification of Catalposide Metabolites in Human Liver and Intestinal Preparations and Characterization of the Relevant Sulfotransferase, UDP-glucuronosyltransferase, and Carboxylesterase Enzymes [PDF]
Pharmaceutics, 2019 Catalposide, an active component of Veronica species such as Catalpa ovata and Pseudolysimachion lingifolium, exhibits anti-inflammatory, antinociceptic, anti-oxidant, hepatoprotective, and cytostatic activities.
Deok-Kyu Hwang +8 more
doaj +2 more sources