Results 31 to 40 of about 53,054 (215)

Strong Inhibition of Celastrol Towards UDP-Glucuronosyl Transferase (UGT) 1A6 and 2B7 Indicating Potential Risk of UGT-Based Herb-Drug Interaction

Molecules, 2012
Celastrol, a quinone methide triterpene isolated from <em>Tripterygium wilfordii</em> Hook F., has various biochemical and pharmacological activities, and is now being developed as a promising anti-tumor agent.
Qi Wang, Ru-Meng Ma, Jian-Ping Deng, Gang Li, Liang Wang, Jun Yuan, Yong-Sheng Zhang, Xing-Chun Gao, Yan-Yang Tu   +8 more
doaj   +1 more source

Gene excavation and expression analysis of CYP and UGT related to the post modifying stage of gypenoside biosynthesis in Gynostemma pentaphyllum (Thunb.) Makino by comprehensive analysis of RNA and proteome sequencing.

PLoS ONE, 2021
Previous studies have revealed that gypenosides produced from Gynostemma pentaphyllum (Thunb.) Makino are mainly dammarane-type triterpenoid saponins with diverse structures and important biological activities, but the mechanism of diversity for ...
Yangmei Zhang, Qicong Chen, Yuanheng Huang, Ruiqiang Zhao, Jian Sun, Xidong Yuan, Huiming Xu, Huiyu Liu, Yaosheng Wu   +8 more
doaj   +2 more sources

Gossypol Exhibits a Strong Influence Towards UDP-Glucuronosyltransferase (UGT) 1A1, 1A9 and 2B7-Mediated Metabolism of Xenobiotics and Endogenous Substances

Molecules, 2012
Gossypol, the polyphenolic constituent isolated from cottonseeds, has been used as a male antifertility drug for a long time, and has been demonstrated to exhibit excellent anti-tumor activity towards multiple cancer types.
Liang Wang, Jian-Ping Deng, Jia-Jiu Yao, Hai-Rong Li, Gan Li, Cui-Min Hu, Zhong-Ze Fang, Jun Yuan, Yan-Yang Tu, Yong-Sheng Zhang   +9 more
doaj   +1 more source

Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans

Drug Metabolism and Pharmacokinetics, 2017
More than 20% of clinically used drugs are glucuronidated by a microsomal enzyme UDP-glucuronosyltransferase (UGT). Inhibition or induction of UGT can result in an increase or decrease in blood drug concentration.
R. Fujiwara, Emiko Yoda, R. Tukey
semanticscholar   +1 more source

Functional Characterization of Hepatocytes for Cell Transplantation: Customized Cell Preparation for Each Receptor

Cell Transplantation, 2010
The first indication of hepatocyte transplantation is inborn liver-based metabolic disorders. Among these, urea cycle disorders leading to the impairment to detoxify ammonia and Crigler-Najjar Syndrome type I, a deficiency in the hepatic UDP ...
A. Bonora-Centelles, M. T. Donato, A. Lahoz, E. Pareja, J. Mir, J. V. Castell, M. J. Gómez-Lechón   +6 more
doaj   +1 more source

Revisiting the Latency of Uridine Diphosphate-Glucuronosyltransferases (UGTs)—How Does the Endoplasmic Reticulum Membrane Influence Their Function?

Pharmaceutics, 2017
Uridine diphosphate-glucuronosyltransferases (UGTs) are phase 2 conjugation enzymes mainly located in the endoplasmic reticulum (ER) of the liver and many other tissues, and can be recovered in artificial ER membrane preparations (microsomes).
Yuejian Liu, Michael W. H. Coughtrie
doaj   +1 more source

Demethylzeylasteral Exhibits Strong Inhibition towards UDP-Glucuronosyltransferase (UGT) 1A6 and 2B7

Molecules, 2012
Inhibition of UDP-glucuronosyltransferase (UGT) isoforms can result in severe clinical results, including clinical drug-drug interactions (DDI) and metabolic disorders of endogenous substances.
Xiao-Qi Ji, Lian-Hua Cheng, Jin-Wen Zhao, Min Chen, Gui-Hua Wang   +4 more
doaj   +1 more source

Apalutamide treatment and refractory hypothyroidism: effects of apalutamide on levothyroxine metabolism

European Thyroid Journal
Apalutamide, a selective androgen receptor antagonist, is a new treatment for prostate cancer. Among the side effects observed during apalutamide treatment, an increased risk of hypothyroidism has been reported, particularly in patients previously ...
Florie Quattrochi, Solange Grunenwald, Philippe Caron   +2 more
doaj   +1 more source

Polymorphic expression of UDP-glucuronosyltransferase UGTlA gene in human colorectal cancer.

PLoS ONE, 2013
BackgroundPolymorphism of genes encoding drug-metabolizing enzymes is known to play an important role in increased susceptibility of colorectal cancer. UGT1A gene locus has been suggested to define tissue-specific glucuronidation activity.
Min Wang, De-Feng Sun, Shuai Wang, Ying Qing, Shuo Chen, Dong Wu, Ying-Min Lin, Ji-Zhuang Luo, Yan-Qing Li   +8 more
doaj   +1 more source

Genotype–Phenotype Correlations of Monoallelic PFIC Variants in Pediatric Liver Disease: A Multicenter Retrospective Cohort Study

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Progressive familial intrahepatic cholestasis (PFIC) is classically caused by biallelic pathogenic variants, yet monoallelic variants of uncertain significance (VUS) in PFIC‐associated genes are increasingly identified in children with cholestasis, creating diagnostic uncertainty.
Brett J. Hoskins, Tiziano Pramparo, Chaowapong Jarasvaraparn, Michael J. Wilsey, Voytek Slowik, Lakshmi Kunam, Janis M. Stoll, Ruben E. Quiros‐Tejeira, Simon Lam, Wikrom Karnsakul   +9 more
wiley   +1 more source