Results 51 to 60 of about 72,405 (234)

17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α

Acta Pharmaceutica Sinica B, 2016
UDP-glucuronosyltransferase 1A9 (UGT1A9) is a major phase II enzyme responsible for elimination of drugs and endogenous molecules. Clinical data have shown increased elimination of UGT1A9 substrates in pregnant women or oral contraceptive users, but the ...
Sung-joon Cho, Miaoran Ning, Yanyan Zhang, Leah H. Rubin, Hyunyoung Jeong   +4 more
doaj   +1 more source

Cross layer techniques for flexible transport protocol using UDP-Lite over a satellite network [PDF]

, 2005
Traditional real-time multimedia and streaming services have utilised UDP over RTP. Wireless transmission, by its nature, may introduce a variable, sometimes high bit error ratio. Current transport layer protocols drop all corrupted packets, in contrast,
Stanislaus, William, Fairhurst, Gorry, Radzik, José   +2 more
core  

Deficient UDP-glucuronosyltransferase detoxification enzyme activity in the small intestinal mucosa of patients with coeliac disease.

, 2006
BACKGROUND: Small intestinal malignancies in humans are rare; however, patients with coeliac disease have a relatively high risk for such tumours.
Jansen, J.B.M.J., Roelofs, H.M.J., Goerres, M.S., Peters, W.H.M.   +3 more
core   +1 more source

Variability of human hepatic UDP-glucuronosyltransferase activity

, 1999
The availability of a unique series of liver samples from human subjects, both control patients (9) and those with liver disease (6; biliary atresia (2), retransplant, chronic tyrosinemia type I, tyrosinemia, Wilson's disease) allowed us to characterize ...
Radominska-Pandya, Anna, Little, JM, Frame, L, Kuipers, F, Vonk, R, Drake, RR, Drake, Richard, Kuipers, F; id_orcid, Kuipers, Folkert, Little, Joanna, Frame, Lynn, Mackenzie, Peter, Lester, Roger, Mackenzie, PI, Radominska-Pandya, A, Lester, R, Vonk, Roel   +16 more
core   +1 more source

Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions

, 2013
Pyrethroid insecticides are used to control diseases spread by arthropods. We have developed a suite of pyrethroid mimetic activity-based probes (PyABPs) to selectively label and identify P450s associated with pyrethroid metabolism.
O'Neill, Paul, Paine, Mark, Henderson, Colin, Hong, David W., Hong, David, Cravatt, Benjamin F., O'Neill, Paul M., Henderson, Colin J., Mahmoud, Hanafy, Finn, Robert D., Paine, Mark J. I., Finn, Robert, Ismail, Hanafy, Wright, Aaron T., Cravatt, Benjamin, Wright, Aaron, Paine, Mark; id_orcid, Hemingway, Janet, Ismail, Hanafy M.   +18 more
core   +1 more source

Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?

Case Reports in Medicine, 2011
Ceftriaxone (cfx), a third-generation cephalosporin antibiotic, leads to transient cholelithiasis in some children, also known as pseudolithiasis. However, the underlying pathogenetic mechanism of this adverse effect has not yet been elucidated.
Andrew Fretzayas, Olga Liapi, Anna Papadopoulou, Polyxeni Nicolaidou, Alexandra Stamoulakatou   +4 more
doaj   +1 more source

Prevalence of UDP-glucuronosyltransferase polymorphisms (UGT1A6∗2, 1A7∗12, 1A8∗3, 1A9∗3, 2B7∗2, and 2B15∗2) in a

Saudi Pharmaceutical Journal, 2017
Glucuronidation is an important phase II pathway responsible for many endogenous substances and drug metabolism. The present work evaluated allele frequencies of certain UDP-glucuronosyl-transferases (UGT 1A6∗2, A7∗12, A8∗3, A9∗3, 2B7∗2, and 2B15∗2) in ...
Khalid M. Alkharfy, Basit L. Jan, Sibtain Afzal, Fahad I. Al-Jenoobi, Abdullah M. Al-Mohizea, Saleh Al-Muhsen, Rabih Halwani, Mohammad K. Parvez, Mohammed S. Al-Dosari   +8 more
doaj   +1 more source

G‐quadruplex‐enhanced circular single‐stranded DNA (G4‐CSSD) adsorption of miRNA to inhibit colon cancer progression

Cancer Medicine, 2023
Background Chromosomal heterogeneity leads to the abnormal expression and mutation of tumor‐specific genes. Drugs targeting oncogenes have been extensively developed.
Haidong Wu, Weilong Zhong, Ronghua Zhang, Yuping Ding, Chunhua Qu, Keguan Lai, Zheng Pang, Shan Yin, Guangling Zhang, Shuang Chen   +9 more
doaj   +1 more source

[UDP-glucuronosyltransferase].

Nihon eiseigaku zasshi. Japanese journal of hygiene, 2002
UDP-glucuronosyltransferases (UGTs) represent a family of enzymes that glucuronidate many internal substances and drugs. This family acts as a drug metabolism phase II reactor in the liver and comprises one of the major protective mechanisms from toxic chemical substances. UGTs have two subfamilies; UGT1 and UGT2.
Yoshihiro, Maruo, Hiroshi, Sato
openaire   +1 more source

Effect of oral administration of ursodeoxycholic acid on rat hepatic and intestinal UDP-glucuronosyltransferase

, 1994
The effect of oral administration of the bile acid ursodeoxycholic acid on rat hepatic and intestinal microsomal UDP-glucuronosyltransferase was studied. The bile acid was administered during 8 days at a daily dose of 500 mg/kg body weight.
Marcelo G. Roma, Aldo D. Mottino, Emilio A. Rodríguez Garay, Marcelo G. Luquita, Enrique J. Sánchez Pozzi, Viviana A. Catania   +5 more
core   +1 more source