Results 61 to 70 of about 15,984 (223)
Case Reports in Medicine, 2011 Ceftriaxone (cfx), a third-generation cephalosporin antibiotic, leads to transient cholelithiasis in some children, also known as pseudolithiasis. However, the underlying pathogenetic mechanism of this adverse effect has not yet been elucidated.
Andrew Fretzayas +4 more
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The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids [PDF]
, 2016 At a population level there is growing evidence for the beneficial effects of dietary flavonoids on health. However there is extensive heterogeneity in the response to increased intake, which is likely mediated via wide inter-individual variability in ...
Cassidy, Aedin, Minihane, Anne-Marie
core +1 more source
Pharmacogenomics of human UDP-glucuronosyltransferase enzymes [PDF]
The Pharmacogenomics Journal, 2003 UDP-glucuronosyltransferase (UGT) enzymes comprise a superfamily of key proteins that catalyze the glucuronidation reaction on a wide range of structurally diverse endogenous and exogenous chemicals. Glucuronidation is one of the major phase II drug-metabolizing reactions that contributes to drug biotransformation.
openaire +2 more sources
The Plant Genome, Volume 19, Issue 2, June 2026.Abstract Drought is a critical challenge to wheat (Triticum aestivum L.) productivity. The quantitative complexity of drought tolerance makes breeding for this trait difficult. Developing near‐isogenic lines (NILs) targeting quantitative trait locus (QTL) for 1000‐grain weight (TGW) under drought stress can effectively identify key mechanisms and genes.
Joanne D. Caguiat +4 more
wiley +1 more source
Saudi Pharmaceutical Journal, 2017 Glucuronidation is an important phase II pathway responsible for many endogenous substances and drug metabolism. The present work evaluated allele frequencies of certain UDP-glucuronosyl-transferases (UGT 1A6∗2, A7∗12, A8∗3, A9∗3, 2B7∗2, and 2B15∗2) in ...
Khalid M. Alkharfy +8 more
doaj +1 more source
FEBS Open Bio, Volume 16, Issue 5, Page 906-920, May 2026.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Cancer Medicine, 2023 Background Chromosomal heterogeneity leads to the abnormal expression and mutation of tumor‐specific genes. Drugs targeting oncogenes have been extensively developed.
Haidong Wu +9 more
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The role of lipid metabolism in neuronal senescence
FEBS Open Bio, Volume 16, Issue 5, Page 857-869, May 2026.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
PLoS ONE, 2014 BackgroundOxidative stress is a major mediator of adverse outcome after kidney transplantation. Bilirubin is produced by heme oxygenase-1 (HO-1), catalyzed by UDP-glucuronosyltransferase (UGT1A1), and has potential as an antioxidant.
Jung Pyo Lee +9 more
doaj +1 more source
[UDP-glucuronosyltransferase].
Nihon eiseigaku zasshi. Japanese journal of hygiene, 2002 UDP-glucuronosyltransferases (UGTs) represent a family of enzymes that glucuronidate many internal substances and drugs. This family acts as a drug metabolism phase II reactor in the liver and comprises one of the major protective mechanisms from toxic chemical substances. UGTs have two subfamilies; UGT1 and UGT2.
Yoshihiro, Maruo, Hiroshi, Sato
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