Results 61 to 70 of about 72,405 (234)

Serum bilirubin affects graft outcomes through UDP-glucuronosyltransferase sequence variation in kidney transplantation.

PLoS ONE, 2014
BackgroundOxidative stress is a major mediator of adverse outcome after kidney transplantation. Bilirubin is produced by heme oxygenase-1 (HO-1), catalyzed by UDP-glucuronosyltransferase (UGT1A1), and has potential as an antioxidant.
Jung Pyo Lee, Do Hyoung Kim, Seung Hee Yang, Jin Ho Hwang, Jung Nam An, Sang Il Min, Jongwon Ha, Yun Kyu Oh, Yon Su Kim, Chun Soo Lim   +9 more
doaj   +1 more source

Evidence for the intraluminal positioning of p-nitrophenol UDP-glucuronosyltransferase activity in rat liver microsomal vesicles

, 1994
Addition of p-nitrophenol and UDP-glucuronic acid to rat hepatic microsomes enhanced the MgATP-stimulated Ca2+ sequestration. This stimulatory effect was more explicit in the presence of the activator of glucuronidation, UDP-N-acetylglucosamine.
Fulceri, R., Benedetti, A., Giunti, R., Mandl, J., Bánhegyi, G., Gamberucci, A.   +5 more
core   +1 more source

The First Aspartic Acid of the DQxD Motif for Human UDP-Glucuronosyltransferase 1A10 Interacts with UDP-Glucuronic Acid during Catalysis

, 2007
All UDP-glucuronosyltransferase enzymes (UGTs) share a com-mon cofactor, UDP-glucuronic acid (UDP-GlcUA). The binding site for UDP-GlcUA is localized to the C-terminal domain of UGTs on the basis of amino acid sequence homology analysis and crystal ...
Bratton, S. M., Anna Radominska-pandya, Radominska-Pandya, A., Zielinska, A. K., Stacie M. Bratton, Xiong, Y., Miley, M. J., Adrian Goldman, Michael J. Miley, Patana, A.-S., Goldman, A., Yan Xiong, Agnieszka K. Zielinska, Matt R. Redinbo, Anne-sisko Patana, Redinbo, M. R., Moshe Finel, Miller, G. P., Finel, M., Grover P. Miller   +19 more
core   +1 more source

Thiamethoxam Resistance in Aphis gossypii Glover Relies on Multiple UDP-Glucuronosyltransferases

Frontiers in Physiology, 2018
Uridine diphosphate (UDP)-glycosyltransferases (UGTs) are major phase II enzymes that conjugate a variety of small lipophilic molecules with UDP sugars and alter them into more water-soluble metabolites. Therefore, glucosidation plays a major role in the
Yiou Pan, Fayi Tian, Xiang Wei, Yongqiang Wu, Xiwu Gao, Jinghui Xi, Qingli Shang   +6 more
doaj   +1 more source

Association of UDP-glucuronosyltransferase 1A9 polymorphisms with adverse reactions to catechol-O-methyltransferase inhibitors in Parkinson's disease patients

, 2012
Purpose: To investigate the association between adverse reactions to catechol-O-methyltransferase (COMT) inhibitors and the UDP- glucuronosyltransferase 1A9 genotypes UGT1A91b and UGT1A93a, which were previously identified in individual cases of COMT ...
Riboldazzi G., Ferrari M., Marino F., Blandini F., Cosentino M., Martignoni E., Bono G.   +6 more
core   +1 more source

A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders[S]

Journal of Lipid Research, 2013
Increased levels of bile acids (BAs) due to the various hepatic diseases could interfere with the metabolism of xenobiotics, such as drugs, and endobiotics including steroid hormones.
Zhong-Ze Fang, Rong-Rong He, Yun-Feng Cao, Naoki Tanaka, Changtao Jiang, Kristopher W. Krausz, Yunpeng Qi, Pei-Pei Dong, Chun-Zhi Ai, Xiao-Yu Sun, Mo Hong, Guang-Bo Ge, Frank J. Gonzalez, Xiao-Chi Ma, Hong-Zhi Sun   +14 more
doaj   +1 more source

Hematologically important mutations: Bilirubin UDP-glucuronosyltransferase gene mutations in Gilbert and Crigler–Najjar syndromes

, 2005
Gilbert and Crigler-Najjar syndromes are familial unconjugated hyperbilirubinemias caused by genetic lesions involving a single complex locus encoding for bilirubin UDP-glucuronosyltransferase (UGT1A1) gene.
Elísio Costa, Costa, Elísio
core   +1 more source

The clinical application of UGT1A1 pharmacogenetic testing: Gene-environment interactions

Human Genomics, 2010
Over the past decade, the number of pharmacogenetic tests has increased considerably, allowing for the development of our knowledge of their clinical application.
Marques Sara, Ikediobi Ogechi N
doaj   +1 more source

Epigenetic regulation of the tissue-specific expression of human UDP-glucuronosyltransferase (UGT) 1A10.

Biochemical Pharmacology, 2014
Human UDP-glucuronosyltransferase (UGT) 1A10 is not expressed in the liver; however, UGT1A10 is highly expressed in the intestine, contributing to presystemic first-pass metabolism. Earlier studies revealed that hepatocyte nuclear factor (HNF) 1α and Sp1,
Shingo Oda, T. Fukami, T. Yokoi, M. Nakajima   +3 more
semanticscholar   +1 more source

UDP-Glucose Analogues as Inhibitors and Mechanistic Probes of UDP-Glucose Dehydrogenase

, 2016
UDP-glucose dehydrogenase catalyzes the NAD+-dependent 2-fold oxidation of UDP-glucose to give UDP-glucuronic acid. The putative aldehyde intermediate is not released from the active site and is presumably tightly bound.
Martin E. Tanner (1443997), Robert E. Campbell (112695)   +1 more
core   +1 more source