Results 81 to 90 of about 72,405 (234)

Mapping the UDP-glucuronic Acid Binding Site in UDP-glucuronosyltransferase-1A10 by Homology-Based Modeling: Confirmation with Biochemical Evidence

, 2016
The UDP-glucuronosyltransferase (UGT) isozyme system is critical for protecting the body against endogenous and exogenous chemicals by linking glucuronic acid donated by UDP-glucuronic acid to a lipophilic acceptor substrate.
Rajat Banerjee (250017), Amanda Garza (2430094), Matthew W. Pennington (2430088), Ida S. Owens (2430091)   +3 more
core   +3 more sources

A Comparative Analysis of Michaelis-Menten, Hill, and Allosteric Models in Drug Metabolism

Iraqi Journal of Industrial Research
Background: Enzyme Kinetics it is a fundamental part of metabolic biochemistry because it helps to explore the mechanism of action and interaction of all substrates under the influence as well as environmental factors.
Ziyad K. Radeef
doaj   +1 more source

Induction of UDP-glucuronosyltransferase 1A by naturally occurring phytochemicals in human hepatoma cells

Journal of Medical Science, 2014
UDP-glucuronosyltransferases (UGTs) are important detoxification and drug-metabolizing enzymes, which catalyse the glucuronidation of exogenous and endogenous chemicals. The anti-carcinogenic activity of dietary phytochemicals is partly attributed to the
Violetta Krajka-Kuźniak, Adam Krysztofiak, Jarosław Paluszczak   +2 more
doaj   +1 more source

Characterization of Human UDP-Glucuronosyltransferase Isoforms Responsible for the in vitro Glucuronidation of Esculetin

, 2009
Esculetin (6,7-dihydroxycoumarin), is one of coumarin analogs isolated from various plant including Cichorium intybus, Artemisia scoparia and Fraxinus japonica Blume, has been found to exhibit broaden biological effects, such as analgesic, anti ...
梁思成, 张延延, 葛广波, 杨凌, 刘慧鑫   +4 more
core  

Dietary moderately oxidized oil activates the Nrf2 signaling pathway in the liver of pigs

Lipids in Health and Disease, 2012
Background Previous studies have shown that administration of oxidized oils increases gene expression and activities of various enzymes involved in xenobiotic metabolism and stress response in the liver of rats and guinea pigs.
Varady Juliane, Gessner Denise K, Most Erika, Eder Klaus, Ringseis Robert   +4 more
doaj   +1 more source

A Major Genotype in UDP-glucuronosyltransferase 2B15

Drug Metabolism and Pharmacokinetics, 2002
A novel single nucleotide polymorphism (SNP) was found in exon 6 of the UDP-glucuronosyltransferase (UGT) 2B15 gene from healthy Japanese populations. The SNP was as follows: SNP, 020228Toide001; GENE NAME, UGT2B15; ACCESSION NUMBER, U08854, AF180322, and NM_001078; LENGTH, 25 base; 5'-AGCTTGCCAAAAC/AAGGAAAGAAGAA-3'.
TOIDE, Kenji, UMEDA, Shin-ichiro, YAMAZAKI, Hiroshi, TAKAHASHI, Yoshiki, TERAUCHI, Yoshiaki, FUJII, Toshihiko, KAMATAKI, Tetsuya   +6 more
openaire   +2 more sources

Drug metabolizing enzyme activities versus genetic variances for drug of clinical pharmacogenomic relevance

Clinical Proteomics, 2011
Enzymes are critically important in the transportation, metabolism, and clearance of most therapeutic drugs used in clinical practice today. Many of these enzymes have significant genetic polymorphisms that affect the enzyme's rate kinetics.
Wu Alan HB
doaj   +1 more source

Changes in expressions of UDP-glucuronosyltransferases in placenta and fetal liver of rats before birth induced by maternal exposure to bisphenol A during pregnancy

环境与职业医学
BackgroundMaternal exposure to bisphenol A (BPA) during pregnancy is closely related to adverse growth and development conditions such as preterm birth and low birth weight, but the relevant mechanisms are still unclear.
Peili WANG, Jun WANG, Yichen ZHAO, Panjie WANG, Mingyue MA, Zhiwen DUAN, Xiucong PEI, Haiyang YU   +7 more
doaj   +1 more source

Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms

, 2011
Magnolol is a food additive that is often found in mints and gums. Human exposure to this compound can reach a high dose; thus, characterization of magnolol disposition in humans is very important.
Ling Yang, Finel, Moshe, Zhongze Fang, He, Guiyuan, Liang, Sicheng, Hongbo Zhang, Liu, Huixin, Dong, Peipei, 杨凌, Peipei Dong, Fang, Zhongze, Zhang, Hongbo, Moshe Finel, Zhu, Liangliang, Huixin Liu, Liangliang Zhu, Guangbo Ge, Guiyuan He, Ge, Guangbo, Yanyan Zhang, Sicheng Liang, Yang, Ling, Zhang, Yanyan   +22 more
core   +1 more source

Morphine Metabolism in Human Skin Microsomes [PDF]

, 2012
For patients with severe skin wounds, topically applied morphine is an option to induce efficient analgesia due to the presence of opioid receptors in the skin.
Heilmann, S., Küchler, S., Schäfer-Korting, Monika, Küchler, Sarah, Schäfer-Korting, M.   +4 more
core   +1 more source