Results 81 to 90 of about 53,054 (215)

Dietary moderately oxidized oil activates the Nrf2 signaling pathway in the liver of pigs

Lipids in Health and Disease, 2012
Background Previous studies have shown that administration of oxidized oils increases gene expression and activities of various enzymes involved in xenobiotic metabolism and stress response in the liver of rats and guinea pigs.
Varady Juliane, Gessner Denise K, Most Erika, Eder Klaus, Ringseis Robert   +4 more
doaj   +1 more source

A Major Genotype in UDP-glucuronosyltransferase 2B15

Drug Metabolism and Pharmacokinetics, 2002
A novel single nucleotide polymorphism (SNP) was found in exon 6 of the UDP-glucuronosyltransferase (UGT) 2B15 gene from healthy Japanese populations. The SNP was as follows: SNP, 020228Toide001; GENE NAME, UGT2B15; ACCESSION NUMBER, U08854, AF180322, and NM_001078; LENGTH, 25 base; 5'-AGCTTGCCAAAAC/AAGGAAAGAAGAA-3'.
TOIDE, Kenji, UMEDA, Shin-ichiro, YAMAZAKI, Hiroshi, TAKAHASHI, Yoshiki, TERAUCHI, Yoshiaki, FUJII, Toshihiko, KAMATAKI, Tetsuya   +6 more
openaire   +2 more sources

Changes in expressions of UDP-glucuronosyltransferases in placenta and fetal liver of rats before birth induced by maternal exposure to bisphenol A during pregnancy

环境与职业医学
BackgroundMaternal exposure to bisphenol A (BPA) during pregnancy is closely related to adverse growth and development conditions such as preterm birth and low birth weight, but the relevant mechanisms are still unclear.
Peili WANG, Jun WANG, Yichen ZHAO, Panjie WANG, Mingyue MA, Zhiwen DUAN, Xiucong PEI, Haiyang YU   +7 more
doaj   +1 more source

Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1

Acta Pharmaceutica Sinica B, 2017
UDP-glucuronosyltransferase 1A1 (UGT1A1) plays a key role in detoxification of many potentially harmful compounds and drugs. UGT1A1 inhibition may bring risks of drug–drug interactions (DDIs), hyperbilirubinemia and drug-induced liver injury.
Xuewei Cheng, Xia Lv, Hengyan Qu, Dandan Li, Mengmeng Hu, Wenzhi Guo, Guangbo Ge, Ruihua Dong   +7 more
doaj   +1 more source

Drug metabolizing enzyme activities versus genetic variances for drug of clinical pharmacogenomic relevance

Clinical Proteomics, 2011
Enzymes are critically important in the transportation, metabolism, and clearance of most therapeutic drugs used in clinical practice today. Many of these enzymes have significant genetic polymorphisms that affect the enzyme's rate kinetics.
Wu Alan HB
doaj   +1 more source

The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis. [PDF]

Clin Pharmacokinet, 2023
Duthaler U, Bachmann F, Ozbey AC, Umehara K, Parrott N, Fowler S, Krähenbühl S.   +6 more
europepmc   +1 more source

Identification of Human UDP-Glucuronosyltransferase Involved in Gypensapogenin C Glucuronidation and Species Differences. [PDF]

Int J Mol Sci, 2023
Chen J, Qin L, Wu X, Tan D, Lu Y, Du Y, Wu D, He Y.   +7 more
europepmc   +1 more source

The Survival and Physiological Response of Calliptamus abbreviatus Ikonn (Orthoptera: Acrididae) to Flavonoids Rutin and Quercetin

Insects
Insect-resistant substances from plants are important natural resources that human beings can potentially develop and use to control pests. In this study, we explored the adverse effects of rutin and quercetin on grasshopper (Calliptamus abbreviatus), as
Xunbing Huang, Li Zheng, Yueyue Wang
doaj   +1 more source

Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1.

PLoS ONE, 2019
UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme that is found in the endoplasmic reticulum membrane and can reportedly have a large number of amino acid substitutions that result in the reduction of glucuronidation capacity.
Yutaka Takaoka, Atsuko Takeuchi, Aki Sugano, Kenji Miura, Mika Ohta, Takashi Suzuki, Daisuke Kobayashi, Takuji Kimura, Juichi Sato, Nobutaro Ban, Hisahide Nishio, Toshiyuki Sakaeda   +11 more
doaj   +1 more source

Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action. [PDF]

Cells, 2022
Sarfstein R, Nagaraj K, Parikh S, Levy C, Laron Z, Benayahu D, Werner H.   +6 more
europepmc   +1 more source