Bilirubin dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index [PDF]
, 2011 In PressIn humans, bilirubin levels are influenced by different factors. This study aims to evaluate the influence of several nongenetic factors (hematologic data, smoking status, alcohol intake, fasting time, physical activity, oral contraceptive ...
Bronze-da-Rocha, Elsa +7 more
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环境与职业医学BackgroundMaternal exposure to bisphenol A (BPA) during pregnancy is closely related to adverse growth and development conditions such as preterm birth and low birth weight, but the relevant mechanisms are still unclear.
Peili WANG +7 more
doaj +1 more source
Effects of curcumin analogue, 2, 6-bis (2, 5-dimethoxybenzylidene) cyclohexanone (BDMC33) on the activities of drug-metabolizing enzymes in cultured Caco-2 cell model [PDF]
, 2016 Poor systemic delivery of curcumin outside the gut due to its rapid metabolism has severely limited its application to many chronic diseases. Previously, our research group synthesized curcumin analogues 2, 6-bis (2, 5-dimethoxybenzylidene) cyclohexanone
Abas, Faridah +3 more
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Acta Pharmaceutica Sinica B, 2017 UDP-glucuronosyltransferase 1A1 (UGT1A1) plays a key role in detoxification of many potentially harmful compounds and drugs. UGT1A1 inhibition may bring risks of drug–drug interactions (DDIs), hyperbilirubinemia and drug-induced liver injury.
Xuewei Cheng +7 more
doaj +1 more source
The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis. [PDF]
Clin Pharmacokinet, 2023 Duthaler U +6 more
europepmc +1 more source
Gilbert Syndrome and the Development of Antiretroviral Therapy-Associated Hyperbilirubinemia [PDF]
, 2017 BackgroundUnconjugated hyperbilirubinemia results from Gilbert syndrome and from antiretroviral therapy (ART) containing protease inhibitors. An understanding of the interaction between genetic predisposition and ART may help to identify individuals at ...
Bernasconi, Enos +9 more
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Identification of Human UDP-Glucuronosyltransferase Involved in Gypensapogenin C Glucuronidation and Species Differences. [PDF]
Int J Mol Sci, 2023 Chen J +7 more
europepmc +1 more source
InsectsInsect-resistant substances from plants are important natural resources that human beings can potentially develop and use to control pests. In this study, we explored the adverse effects of rutin and quercetin on grasshopper (Calliptamus abbreviatus), as
Xunbing Huang, Li Zheng, Yueyue Wang
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Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1.
PLoS ONE, 2019 UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme that is found in the endoplasmic reticulum membrane and can reportedly have a large number of amino acid substitutions that result in the reduction of glucuronidation capacity.
Yutaka Takaoka +11 more
doaj +1 more source
Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action. [PDF]
Cells, 2022 Sarfstein R +6 more
europepmc +1 more source