Results 101 to 110 of about 72,405 (234)

Bile bilirubin pigment analysis in disorders of bilirubin metabolism in early infancy

, 2001
BACKGROUNDEarly and accurate diagnosis of Crigler-Najjar syndrome, which causes prolonged unconjugated hyperbilirubinaemia in infancy, is important, as orthotopic liver transplantation is the definitive treatment.
M A Preece, McKiernan, P.J., Kelly, D.A., P J McKiernan, Kelly, Deirdre, B Burchell, Clarke, Douglas, Burchell, B, Lee, W. S., Beath, Susan, Baty, D, Clarke, D. J., Preece, M.A., Burchell, B., McKiernan, P. J., Lee, Way Seah, S V Beath, Clarke, DJ, D J Clarke, Clarke, D.J., Preece, Mary, Lee, WS, D Baty, W S Lee, Lee, W S, Beath, S.V., D A Kelly, Baty, D., Preece, M. A., Beath, S. V., McKiernan, Patrick, Kelly, D. A.   +31 more
core   +1 more source

Isolation and characterisation of a new hepatic bilirubin UDP-glucuronosyltransferase Absence from Gunn rat liver

, 1992
A novel UDP-glucuronosyltransferase that conjugates bilirubin IXα, bilirubin monoglucuronide and an arylalkanoic acid was purified to homogeneity from clofibrate treated Wistar rats.
Brian Burchell, Keen, Jeffrey N., Jeffrey N. Keen, Clarke, Douglas J., Douglas J. Clarke, Burchell, Brian   +5 more
core   +1 more source

Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model. [PDF]

Drug Metab Dispos, 2022
Mennillo E, Yang X, Weber AA, Maruo Y, Verreault M, Barbier O, Chen S, Tukey RH.   +7 more
europepmc   +1 more source

Structural analysis of filarial B. malayi intestinal UDP-glucuronosyltransferase (Bm-UGT).

, 2019
(A) Schematic representation of the Bm-UGT protein domains. (B) Structure model of the UDP-glucuronosyltransferase generated using SWISS-MODEL and PDB ID: 5NLM (UDP-glucosyltransferase from Polygonum tinctorium).
Alyssa R. Lindrose (7377584), M. Gordon Joyce (7377578), Rebekah T. Taylor (7377581), Spencer L. Sterling (7377587), Thomas B. Nutman (7377593), Alexander F. Flynn (7377575), Edward Mitre (292571), Sasisekhar Bennuru (150300), C. Paul Morris (7377590)   +8 more
core   +1 more source

Stereoselective Covalent Adduct Formation of Acyl Glucuronide Metabolite of Nonsteroidal Anti-Inflammatory Drugs with UDP-Glucuronosyltransferase. [PDF]

Int J Mol Sci, 2022
Kawase A, Yamashita R, Yoshizato T, Yoshikawa M, Shimada H, Iwaki M.   +5 more
europepmc   +1 more source

Udp-glucuronosyltransferase 1 Gene Promoter Polymorphism Is Associated With Increased Serum Bilirubin Levels And Cholecystectomy In Patients With Sickle Cell Anemia [1]

, 2015
[No abstract available]642160162Bosma, P.J., Chowdury, J.R., Bakker, C., The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome (1995) N. Engl. J. Med., 333, pp.
Fertrin K.Y., Assis A.M., Costa F.F., Saad S.T.O., Melo M.B.   +4 more
core   +1 more source

Enantioselective Inhibition of Carprofen Towards UDP-glucuronosyltransferase (UGT) 2B7

, 2015
UDP-glucuronosyltransferases (UGTs)-catalyzed glucuronidation conjugation reaction plays an important role in the elimination of many important clinical drugs and endogenous substances.
Wang, Haina, Sun, Dong-Xue, Wang, Li-Xuan, Zeng, Jia, Cao, Yun-Feng, Hong, Mo, Huang, Ting, Chen, Jian-Xing, Fang, Zhong-Ze   +8 more
core   +1 more source

Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver. [PDF]

Drug Metab Dispos, 2022
Sharma S, Ahire D, Basit A, Lajoie M, Wang C, Lee MS, Blithe DL, Amory JK, Singh DK, Heyward S, Prasad B.   +10 more
europepmc   +1 more source

Discovery and Characterization of the Key Constituents in Ginkgo biloba Leaf Extract With Potent Inhibitory Effects on Human UDP-Glucuronosyltransferase 1A1. [PDF]

Front Pharmacol, 2022
Pang HL, Zhu GH, Zhou QH, Ai CZ, Zhu YD, Wang P, Dou TY, Xia YL, Ma H, Ge GB.   +9 more
europepmc   +1 more source

Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?

Proceedings of the National Academy of Sciences of the United States of America, 1998
E. Beutler, T. Gelbart, A. Demina
semanticscholar   +1 more source