Results 91 to 100 of about 15,984 (223)

La farmacogenetica dei farmaci antitumorali [PDF]

, 2014
La variabilità individuale nella risposta ai farmaci è molto importante in quanto può condizionare la riuscita di un trattamento farmacologico ed è dovuta, in gran parte, al profilo genetico.
IOFRIDA, CATERINA
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Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa [PDF]

, 2017
Carminic acid is a widely applied red colorant that is still harvested from insects because its biosynthesis is not fully understood. Here, the authors identify and characterize a membrane-bound C-glucosyltransferase catalyzing the final step during ...
A Radominska-Pandya, A Radominska-Pandya, A Rath, A Serrano, A Shevchenko, C Senay, D Pompon, DA Benson, DD Gadgil, F Pankewitz, HL Flores-Alatorre, J Magdalou, J Piel, J Piel, J Velíšek, J Wouters, K Lech, KS Brown, KW Bock, L Hernández-Hernández Fde, M Ouzzine, M Ouzzine, PA Joshi, R Kannangara, RD Finn, RLL Kellner, RLL Kellner, RLL Kellner, RW Dapson, S Caselín-Castro, S Caselín-Castro, SJ Ahn, ST Ramirez-Puebla, T Eisner, T Eisner   +34 more
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A Comparative Analysis of Michaelis-Menten, Hill, and Allosteric Models in Drug Metabolism

Iraqi Journal of Industrial Research
Background: Enzyme Kinetics it is a fundamental part of metabolic biochemistry because it helps to explore the mechanism of action and interaction of all substrates under the influence as well as environmental factors.
Ziyad K. Radeef
doaj   +1 more source

Induction of UDP-glucuronosyltransferase 1A by naturally occurring phytochemicals in human hepatoma cells

Journal of Medical Science, 2014
UDP-glucuronosyltransferases (UGTs) are important detoxification and drug-metabolizing enzymes, which catalyse the glucuronidation of exogenous and endogenous chemicals. The anti-carcinogenic activity of dietary phytochemicals is partly attributed to the
Violetta Krajka-Kuźniak, Adam Krysztofiak, Jarosław Paluszczak   +2 more
doaj   +1 more source

Irinotecan pathway genotype analysis to predict pharmacokinetics [PDF]

, 2003
PURPOSE: The purpose was to explore the relationships between irinotecan disposition and allelic variants of genes coding for adenosine triphosphate binding cassette transporters and enzymes of putative relevance for irinotecan ...
Baker, S.D. (Sharyn), Karlsson, M.O., Marsh, S. (Steven), Mathijssen, A.H.J. (Ron), McLeod, H.L. (Howard), Sparreboom, A. (Alex), Verweij, J. (Jaap), Xie, R. (Rujia)   +7 more
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mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft [PDF]

, 2008
Background Interactions between the gene products encoded by the mitochondrial and nuclear genomes play critical roles in eukaryotic cellular function. However, the effects mitochondrial DNA (mtDNA) levels have on the nuclear transcriptome have not been ...
Darren Magda, Philip Lecane, Julia Prescott, Patricia Thiemann, Xuan Ma, Patricia K Dranchak, Donna M Toleno, Krishna Ramaswamy, Kimberly D Siegmund, Joseph G Hacia   +9 more
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Dietary moderately oxidized oil activates the Nrf2 signaling pathway in the liver of pigs

Lipids in Health and Disease, 2012
Background Previous studies have shown that administration of oxidized oils increases gene expression and activities of various enzymes involved in xenobiotic metabolism and stress response in the liver of rats and guinea pigs.
Varady Juliane, Gessner Denise K, Most Erika, Eder Klaus, Ringseis Robert   +4 more
doaj   +1 more source

Glucuronidation by UGT1A1 Is the Dominant Pathway of the Metabolic Disposition of Belinostat in Liver Cancer Patients [PDF]

, 2013
10.1371/journal.pone.0054522PLoS ...
A Cashen, A Tumber, AL Yoder Graber, Andrea Li-Ann Wong, Anthony Chan, Boon-Cher Goh, BS Mann, C Marco, CP Strassburg, CS Mitsiades, E Beutler, F Innocenti, F Innocenti, G Giaccone, HJ Mackay, How-Sung Lee, Jacqueline Ramírez, Jie-Ying Amelia Lau, JM Hoskins, John Luk, L Iyer, LH Du, Ling-Zhi Wang, LZ Wang, Mark J. Ratain, Mei-Yi Michelle Chan, MJ Peart, N Tanji, NL Steele, NS Wong, PA Marks, Paul C. Ho, PJ Bosma, RA Howman, RL Piekarz, RL Piekarz, RM Balliet, Robert Lim, S Clive, SA Bapat, Seow-Ching Wan, SG Gray, Sherry Ansher, Soo-Chin Lee, SP Kang, SR Babu, SS Ramalingam, T Izukawa, T Shiraga, W Yeo, Win-Lwin Thuya, Winnie Yeo, Y Dai, Ying-Kiat Zee, YS Na   +54 more
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The effects of zinc sulfate on ethyl glucuronide immunoassay urine testing [PDF]

, 2016
Published research in the Journal of Analytical Toxicology and the American Society for Clinical Pathology has confirmed that the presence of Zinc Sulfate in adulterated urine samples can influence the testing results using EMIT and ELISA immunoassay ...
Cawley, Shanna Marie
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Drug metabolizing enzyme activities versus genetic variances for drug of clinical pharmacogenomic relevance

Clinical Proteomics, 2011
Enzymes are critically important in the transportation, metabolism, and clearance of most therapeutic drugs used in clinical practice today. Many of these enzymes have significant genetic polymorphisms that affect the enzyme's rate kinetics.
Wu Alan HB
doaj   +1 more source