Results 21 to 30 of about 53,054 (215)

Population genetic research of the mutation in ugt1a1 gene associated with reduced activity of liver UDP-glucuronosyltransferase A1

Фундаментальная и клиническая медицина, 2020
Aim. To explore allele and genotype frequencies of the rs8175347 polymorphism within the UGT1A1 gene in Kemerovo Region. Materials and Methods. The study sample included 64 male and 68 female inhabitants of the Kemerovo Region.
A. N. Volkov
doaj   +1 more source

Piscine UDP-glucuronosyltransferase 1B [PDF]

Aquatic Toxicology, 2007
Glucuronidation is an important detoxification pathway for organic pollutants in fish. We report here the isolation and characterisation of UDP-glucuronosyltransferases (UGT) genes from the closely related marine flatfish, plaice (Pleuronectes platessa) and flounder (Platichthys flesus).
Leaver, Michael, Wright, Joy, Hodgson, Paul, Boukouvala, Evridiki, George, Stephen   +4 more
openaire   +3 more sources

Overcoming Drug Resistance through the Development of Selective Inhibitors of UDP-Glucuronosyltransferase Enzymes. [PDF]

J Mol Biol, 2019
Drug resistance is a major cause of cancer-related mortality. Glucuronidation of drugs via elevation of UDP-glucuronosyltransferases (UGT1As) correlates with clinical resistance. The nine UGT1A family members have broad substrate specificities attributed
Osborne MJ, Coutinho de Oliveira L, Volpon L, Zahreddine HA, Borden KLB.   +4 more
europepmc   +2 more sources

UDP-glucuronosyltransferase is involved in susceptibility of Chironomus kiiensis Tokunaga, 1936 (Diptera: Chironomidae) to insecticides

Ecotoxicology and Environmental Safety, 2023
UDP-glucuronosyltransferases (UGTs) could transform various exogenous and endogenous compounds, which help detoxification of pesticides in insects. To investigate the role of UGTs in the detoxification metabolism of insecticides in Chironomus kiiensis ...
Chengcheng Fan, Zexiao Cui, Tianying Yang, Lili Sun, Chuanwang Cao   +4 more
doaj   +1 more source

UDP-Glucuronosyltransferase 2B17 [PDF]

Definitions, 2020
openaire   +2 more sources

Biosynthesis of hydroxyl-linked glucuronides of short-chain bile acids by rat liver 3-hydroxysteroid UDP-glucuronosyltransferase.

Journal of Lipid Research, 1988
Microsomal preparations from livers of Sprague-Dawley rats catalyze the glucuronidation of 3 alpha-hydroxy-5 beta-H (3 alpha, 5 beta) short-chain bile acids (C20-C23), predominantly at the hydroxyl group, while the glucuronidation of 3 beta, 5 beta short-
A Radominska, M D Green, P Zimniak, R Lester, T R Tephly   +4 more
doaj   +1 more source

Metabolism of 2,3-Dehydrosilybin A and 2,3-Dehydrosilybin B: A Study with Human Hepatocytes and Recombinant UDP-Glucuronosyltransferases and Sulfotransferases

Antioxidants, 2021
2,3-Dehydrosilybin A and 2,3-dehydrosilybin B are a pair of enantiomers formed by the oxidation of the natural flavonolignans silybin A and silybin B, respectively.
Jiří Vrba, Barbora Papoušková, Kateřina Lněničková, Pavel Kosina, Vladimír Křen, Jitka Ulrichová   +5 more
doaj   +1 more source

Effects of dietary components on testosterone metabolism via UDP‐glucuronosyltransferase (UGT)

Frontiers in Endocrinology, 2013
The potential interference in testosterone metabolism through ingested substances has ramifications for: i) a range of pathologies such as prostate cancer, ii) medication contra-indications, iii) disruption to the endocrine system, and iv) potential ...
Carl eJenkinson, Andrea ePetroczi, Declan P Naughton   +2 more
doaj   +1 more source

Cascade synthesis of uridine-5′-diphosphate glucuronic acid by coupling multiple whole cells expressing hyperthermophilic enzymes

Microbial Cell Factories, 2019
Background Enzymatic glycan synthesis has leapt forward in recent years and a number of glucuronosyltransferase (EC 2.4.1.17) have been identified and prepared, which provides a guide to an efficient approach to prepare glycans containing glucuronic acid
Dan-Hua Meng, Ran-Ran Du, Lu-Zhou Chen, Meng-Ting Li, Fei Liu, Jin Hou, Yi-Kang Shi, Feng-Shan Wang, Ju-Zheng Sheng   +8 more
doaj   +1 more source

Mutual Influence of Human Cytochrome P450 Enzymes and UDP-Glucuronosyltransferases on Their Respective Activities in Recombinant Fission Yeast

Biomedicines, 2023
Cytochromes P450 (CYPs) and UDP-glucuronosyltransferases (UGTs) are the most important human drug metabolizing enzymes, but their mutual interactions are poorly understood.
Sangeeta Shrestha Sharma, Shishir Sharma, Jie Zhao, Matthias Bureik   +3 more
doaj   +1 more source