Results 11 to 20 of about 53,054 (215)
Molecules, 2012 Efavirenz is a non-nucleoside reverse transcriptase inhibitor used for the treatment of human immunodeficiency virus type 1 infections. Drug interactions of efavirenz have been reported due to in vitro inhibition of CYP2C9, CYP2C19, CYP3A4, and UDP ...
Hye Suk Lee, Lee Hye Suk
exaly +3 more sources
Inhibition of UDP-Glucuronosyltransferase Enzymes by Major Cannabinoids and Their Metabolites. [PDF]
Drug Metab Dispos, 2021 The UDP-glucuronosyltransferase (UGT) family of enzymes play a central role in the metabolism and detoxification of a wide range of endogenous and exogenous compounds.
Nasrin S +5 more
europepmc +2 more sources
Human UDP-Glucuronosyltransferase 2B4 and 2B7 Are Responsible for Naftopidil Glucuronidation in Vitro [PDF]
Frontiers in Pharmacology, 2018 Naftopidil (NAF) is widely used for the treatment of benign prostatic hyperplasia and prevention of prostate cancer in elderly men. These patients receive a combination of drugs, which involves high risk for drug–drug interaction.
Xia-Wen Liu +9 more
doaj +2 more sources
The Functionality of UDP-Glucuronosyltransferase Genetic Variants and their Association with Drug Responses and Human Diseases. [PDF]
J Pers Med, 2021 UDP-glucuronosyltransferases (UGTs) are phase II drug-metabolizing enzymes that metabolize endogenous fatty acids such as arachidonic acid metabolites, as well as many prescription drugs, such as opioids, antiepileptics, and antiviral drugs.
Jarrar Y, Lee SJ.
europepmc +2 more sources
Pharmacogenomics of human UDP-glucuronosyltransferase enzymes [PDF]
The Pharmacogenomics Journal, 2003 UDP-glucuronosyltransferase (UGT) enzymes comprise a superfamily of key proteins that catalyze the glucuronidation reaction on a wide range of structurally diverse endogenous and exogenous chemicals. Glucuronidation is one of the major phase II drug-metabolizing reactions that contributes to drug biotransformation.
C. Guillemette
openaire +3 more sources
UDP-Glucuronosyltransferase (UGT)-mediated attenuations of cytochrome P450 3A4 activity: UGT isoform-dependent mechanism of suppression. [PDF]
Br J Pharmacol, 2020 Cytochrome P450 (CYP, P450) 3A4 is involved in the metabolism of 50% of drugs and its catalytic activity in vivo is not explained only by hepatic expression levels.
Miyauchi Y +6 more
europepmc +2 more sources
Insect Biochemistry and Molecular Biology, 2022 The green peach aphid, Myzus persicae, is a highly damaging, globally distributed crop pest that has evolved multiple resistance to numerous insecticides.
Adam M. Pym +9 more
semanticscholar +1 more source
Pharmacokinetics and Pharmacogenetics of Dabigatran
Рациональная фармакотерапия в кардиологии, 2021 Dabigatran etexilate is a prodrug of dabigatran, a oral direct inhibitor of thrombin. Pharmacokinetics of dabigatran etexilate doesn’t have the disadvantages of vitamin K antagonists.
A. V. Savinova +4 more
doaj +1 more source
UDP-Glucuronosyltransferase 2B15 [PDF]
Definitions, 2020 UDP-glucuronosyltransferase 2B15 (530 aa, ~61 kDa) is encoded by the human UGT2B15 gene. This protein is involved in the catabolism of xenobiotics and steroids.
openaire +2 more sources
UGT84F9 is the major flavonoid UDP-glucuronosyltransferase in Medicago truncatula.
Plant Physiology, 2021 Mammalian phase II metabolism of dietary plant flavonoid compounds generally involves substitution with glucuronic acid. In contrast, flavonoids mainly exist as glucose conjugates in plants, and few plant UDP-glucuronosyltransferase enzymes have been ...
Olubu A. Adiji +5 more
semanticscholar +1 more source