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Diphenylhydantoin Gingival Hyperplasia
Archives of Pediatrics & Adolescent Medicine, 1969DIPHENYLHYDANTOIN (Dilantin) sodium was synthesized in 1908 by Biltz1and introduced as an antiepileptic agent in 1938 by Merritt and Putnam.2Extensive subsequent use of this drug has confirmed its efficacy in controlling epileptic seizures, particularly major motor (grand mal) convulsions.
Herbert L Livingston, Samuel Livingston
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Nifedipine-Induced Gingival Hyperplasia
Drug Intelligence & Clinical Pharmacy, 1986Gingival hyperplasia, a condition characterized by increased amounts of gingival connective tissue, has most commonly been observed in patients receiving phenytoin, but has also been noted in patients receiving cyclosporine and, as in this case report, nifedipine.
Lorie L. Widdup +3 more
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Incidence of diphenylhydantoin gingival hyperplasia
Oral Surgery, Oral Medicine, Oral Pathology, 1972Abstract The incidence of diphenylhydantoin gingival hyperplasia was studied in 173 hospitalized patients who were mainly middle aged and older. The incidence in this series was found to be 53.2 per cent; it was related to the degree of the patients' oral hygiene, while the age, sex, daily dosage of diphenylhydantoin medication, and duration of ...
A.P. Angelopoulos, P.W. Goaz
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Focal gingival hyperplasia in a horse
Journal of the American Veterinary Medical Association, 1993A diagnosis of gingival hyperplasia in a 22-year-old Quarter Horse gelding was confirmed by histologic examination. Clinical signs included difficulty eating hay, and a large, intraoral soft tissue mass measuring 13 x 8 x 4.5 cm. The mass was located in the mucosa on the lingual aspect of the caudal left portion of the mandible, ventral to the base of ...
L H, Handy +3 more
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Verapamil-induced gingival hyperplasia in children
American Heart Journal, 1992Gingival hyperplasia (GH) occurs in 20 % to 40 So of all patients receiving long-term oral phenytoin therapy and phenytoin is probably the most common cause of GH in children and young ado1escents.l Several other drugs including nifedipine, a calcium channel blocker, have been reported infrequently to cause GH.2-4 We report here a similar GH in two ...
Mehta, Ashok V. +2 more
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Phenytoin as a Risk Factor in Gingival Hyperplasia
Therapeutic Drug Monitoring, 1995Fifty-four out-patients with epilepsy who had been taking phenytoin for more than one year were examined for gingival hyperplasia. Approximately 76% of patients showed either mild or no gingival hyperplasia. Lesion severity was then compared statistically to phenytoin dosage and drug concentrations as well as to other clinical and laboratory parameters.
Jana Zvárová +3 more
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