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Chronic lipopolysaccharide exposure promotes cognitive impairments by activating TRPC6-AIM2 inflammasome signaling and the regulation of ginsenoside Rg1 in Trpc6<sup>-/-</sup> mice. [PDF]
Behav Brain FunctFu Y +7 more
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Hepataprotective effects of ginsenoside Rg1 – A review
Journal of Ethnopharmacology, 2017Ginseng has been used as efficient tonic and for the treatment of various diseases including hepatic disorders. Ginseng saponins, also known as ginsenosides, are principal constituents and have been treated to be responsible for disparate ginseng health benefits. The current review mainly focuses on ginsenoside Rg1, a compound isolated from traditional
Zhao Zhang, Nai-Hong Chen, Yan Gao
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Hepatoprotection by Ginsenoside Rg1 in alcoholic liver disease
International Immunopharmacology, 2021Alcoholic hepatitis (AH) has caused serious mortality to the world's population. Despite tremendous efforts to reduce disease burden, effective treatments for this disease are still lacking. Ginsenoside Rg1 (G-Rg1) has been reported to be hepatoprotective in several liver injury models.
Cheng, Yang +3 more
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Ginsenoside Rg1 and ginsenoside Rh1 prevent liver injury induced by acetaminophen in mice
Journal of Food Biochemistry, 2021With the development of technology, drugs are being developed for different purposes. Thus, the rate of drug injury considerably increased worldwide. Liver is the largest detoxification organ in the human body, but it is also the organ most vulnerable to drug damage.
Yunfeng Bi +5 more
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Ginsenoside Rg1 in neurological diseases: From bench to bedside
Acta Pharmacologica Sinica, 2022Ginseng has been used in China as a superior medicinal material for thousands of years that can nourish the five internal organs, calm the mind and benefit wisdom. Due to its anti-inflammatory, antioxidant and neuroprotective activities, one of the active components of ginseng, ginsenoside Rg1, has been extensively investigated in the remedy of brain ...
Shao-Jie, Yang +5 more
openaire +2 more sources
The American Journal of Chinese Medicine, 2006
Enzyme-linked immunosorbent assay (ELISA) systems using anti-ginsenoside Rb1 (G-Rb1) and Rg1 (G-Rg1) monoclonal antibodies (MAbs) were established for pharmacokinetic investigations of G-Rb1 and G-Rg1 in rat serum. The systems not only allowed sensitive detection of G-Rb1 at the level as low as 20 ng/ml and of G-Rg1 at 300 ng/ml, but showed strong ...
Zhi, Chao +2 more
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Enzyme-linked immunosorbent assay (ELISA) systems using anti-ginsenoside Rb1 (G-Rb1) and Rg1 (G-Rg1) monoclonal antibodies (MAbs) were established for pharmacokinetic investigations of G-Rb1 and G-Rg1 in rat serum. The systems not only allowed sensitive detection of G-Rb1 at the level as low as 20 ng/ml and of G-Rg1 at 300 ng/ml, but showed strong ...
Zhi, Chao +2 more
openaire +2 more sources
Biotechnology Letters, 2012
Ginsenosides Re and Rg1 were transformed by recombinant β-glucosidase (Bgp1) to ginsenosides Rg2 and Rh1, respectively. The bgp1 gene consists of 2,496 bp encoding 831 amino acids which have homology to the glycosyl hydrolase families 3 protein domain.
Lin-Hu, Quan +5 more
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Ginsenosides Re and Rg1 were transformed by recombinant β-glucosidase (Bgp1) to ginsenosides Rg2 and Rh1, respectively. The bgp1 gene consists of 2,496 bp encoding 831 amino acids which have homology to the glycosyl hydrolase families 3 protein domain.
Lin-Hu, Quan +5 more
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Ginsenoside Rg1 prevent and treat inflammatory diseases: A review
International Immunopharmacology, 2020Ginseng has been used as reinforcing drugs or for traditional Chinese medicine in aging, inflammation, stress, diabetes mellitus, hepatic diseases and cancer. The aim of this current review is to provide an integrative overview of the uses, relative human diseases and related mechanisms of ginseng.
Yan, Gao +8 more
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Ginsenoside Rg1 inhibits platelet activation and arterial thrombosis
Thrombosis Research, 2014Derived from the root of Panax ginseng C.A.Mey, Panax notoginsenosides (PNS) is a widely used herbal medicine to treat atherothrombotic diseases in Asian medicine. Ginsenoside Rg1 is one of the main compounds responsible for the pharmaceutical actions of PNS.
Qi, Zhou +9 more
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Neuroprotective Effects and Brain Transport of Ginsenoside Rg1
Chinese Journal of Natural Medicines, 2009Aim Ginsenoside Rg1, one of the major ingredients of Panax notoginseng saponins (PNS), has been proven to possess protective effects on the central nerve system (CNS). However, whether ginsenoside Rg1 could efficiently be transported through the blood brain barrier to elicit its neuroprotective effects remains still unclear. The present study was thus
Rui WANG +5 more
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