Results 71 to 80 of about 861,292 (341)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Oil pipeline route optimization using multi-criteria analysis in GIS [PDF]

علوم محیطی, 2017
Introduction: According to distribution requirements and the broad distance between production and consumption centres in Iran, linear infrastructure development plays an important role and should be considered as a vital necessity.
shahram Mohammadi, Ali Akbar Matkan, Seyed Hossain Pourali, Babak Mirbagheri, Parvin Ahmadpour   +4 more
doaj  

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

RICE AREA ESTIMATION USING PARAMETERIZED CLASSIFICATION OF SENTINEL 1A SAR DATA [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2019
A research study was conducted during Rabi 2016 (Samba season) to estimate rice area using SAR data in Tiruvarur district of Tamil Nadu. Multi temporal Sentinel 1A satellite data with VV and VH polarization at 20 m spatial resolution was acquired ...
M. G. Raman, R. Kaliaperumal, S. Pazhanivelan, B. Kannan   +3 more
doaj   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Developing efficient web-based GIS applications [PDF]

, 2010
There is an increase in the number of web-based GIS applications over the recent years. This paper describes different mapping technologies, database standards, and web application development standards that are relevant to the development of web-based ...
Adnan, M., Longley, P., Singleton, A.
core  

Lifting GIS Maps into Strong Geometric Context for Scene Understanding

, 2016
Contextual information can have a substantial impact on the performance of visual tasks such as semantic segmentation, object detection, and geometric estimation.
Díaz, Raúl, Fowlkes, Charless C., Lee, Minhaeng, Schubert, Jochen   +3 more
core   +1 more source

Determining geometric primitives for a 3D GIS : easy as 1D, 2D, 3D? [PDF]

, 2015
Acquisition techniques such as photo modelling, using SfM-MVS algorithms, are being applied increasingly in several fields of research and render highly realistic and accurate 3D models.
De Maeyer, Philippe, De Roo, Berdien, De Wulf, Alain, Lonneville, Britt, Stal, Cornelis   +4 more
core   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Evaluation and zoning of forest fire risk using multi-criteria decision-making techniques and GIS [PDF]

مخاطرات محیط طبیعی, 2018
Forests as the lung of land part of our natural resources have an important role to play in the physical and mental health of living beings. Forest fires in Iran and especially in boreal forests had been devastating effects on the appearance of these ...
Hassan Abedi Gheshlaghi, Khalil Valizadeh Kamran   +1 more
doaj   +1 more source