Results 81 to 90 of about 818,706 (298)

A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers. [PDF]

, 2016
Gross chromosomal rearrangements (GCRs) play an important role in human diseases, including cancer. The identity of all Genome Instability Suppressing (GIS) genes is not currently known.
Bell, Sara N, Clotfelter, Sarah P, de Souza, Jorge ES, de Souza, Sandro J, Fonseca, André F, Kolodner, Richard D, Martinez, Sandra L, Nene, Rahul V, Putnam, Christopher D, Somach, Steven B, Srivatsan, Anjana   +10 more
core   +2 more sources

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

From cells to power cells: harnessing bacterial electron transport for microbial fuel cells (MFCs)

Annals of Microbiology
Microbial fuel cells (MFCs), which use bacterial electron transport mechanisms to generate energy, have become a viable technology for renewable energy production.
Sri Sathya Sandilya Garimella, Sai Vennela Rachakonda, Sai Sowmya Pratapa, Gnana Divya Mannem, Ganesh Mahidhara   +4 more
doaj   +1 more source

An SDI for the GIS-education at the UGent Geography Department [PDF]

, 2011
The UGent Geography Department (GD) (ca. 200 students; 10 professors) has been teaching GIS since the mid 90’s. Ever since, GIS has evolved from Geographic Information Systems, to GIScience, to GIServices; implying that a GIS specialist nowadays has to ...
De Maeyer, Philippe, De Wit, Bart, Maddens, Ruben, Verfaillie, Els   +3 more
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Improving the accuracy of livestock distribution estimates through spatial interpolation

Geospatial Health, 2012
Animal distribution maps serve many purposes such as estimating transmission risk of zoonotic pathogens to both animals and humans. The reliability and usability of such maps is highly dependent on the quality of the input data. However, decisions on how
Ward Bryssinckx, Els Ducheyne, Bernard Muhwezi, Sunday Godfrey, Koen Mintiens, Herwig Leirs, Guy Hendrickx   +6 more
doaj   +1 more source

Geomorphological analysis of the San Domino Island (Tremiti Islands, Southern Adriatic Sea). Results from the 2019 Geomorphological Field Camp of the MSc in Geological Science and Technology (University of Chieti-Pescara)

Journal of Maps, 2020
The 2019 Geomorphological Field Camp at San Domino Island (Tremiti Islands, Southern Adriatic Sea) is the result of geological and geomorphological field work activities carried out by a group of students attending the Geomorphological field mapping ...
Marcello Buccolini, Cristiano Carabella, Giorgio Paglia, Alessandro Cecili, Gianluca Chiarolanza, Camilla Cioria, Camilla Conicella, Antonio D'Alonzo, Laura De Viti, Fedora Di Carlo, Fausto Di Francesco, Mattia Di Luzio, Cristina Di Mango, Elena Di Nardo, Concezio Di Nino, Ludovica Di Renzo, Antonio Di Tollo, Carmela Epifani, Gianluca Esposito, Piero Farabollini, Massimiliano Fazzini, Simone Gioia, Francesco Incani, Vania Mancinelli, Martina Orlando, Davide Pantanella, Davis Peca, Cristiana Picchi, Chiara Puricelli, Alessia Ricci, Federico Serra, Enrico Miccadei   +31 more
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source