Results 71 to 80 of about 818,706 (298)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The mathematical approach for proximity analysis for 3D GIS [PDF]
, 2008 Next generation of GIS software would highly depend on 3D analysis in solving geographic problems. 3D analysis is a very important component for GIS as it defines as decision making tools for geographic features.
Abdul Rahman, Alias, Chen, Tet Khuan
core
, 2018 The article deals with the subject of Polish language education as a carrier of values. Analyzes the proposals of methodological solutions that the student of a modern school meets.
Gis, Anita
core +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Oil pipeline route optimization using multi-criteria analysis in GIS [PDF]
علوم محیطی, 2017 Introduction: According to distribution requirements and the broad distance between production and consumption centres in Iran, linear infrastructure development plays an important role and should be considered as a vital necessity.
shahram Mohammadi +4 more
doaj
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Lifting GIS Maps into Strong Geometric Context for Scene Understanding
, 2016 Contextual information can have a substantial impact on the performance of visual tasks such as semantic segmentation, object detection, and geometric estimation.
Díaz, Raúl +3 more
core +1 more source
Earliest Holocene south Greenland ice sheet retreat within its late Holocene extent [PDF]
, 2014 Early Holocene summer warmth drove dramatic Greenland ice sheet (GIS) retreat. Subsequent insolation-driven cooling caused GIS margin readvance to late Holocene maxima, from which ice margins are now retreating.
Anslow, FS +8 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source