Results 91 to 100 of about 116,518 (256)

Structural characterization of metal binding in human tyrosylprotein sulfotransferase 2, TPST2

Scientific Reports
Tyrosylprotein sulfotransferases (TPSTs) catalyze O-sulfation of tyrosine residues on secreted and membrane proteins, but the molecular basis for their stimulation by metal ions remains unclear.
Minwoo Jin, Chaemin Noh, Jihyeong Yang, Hyunwoo Kim, Soo Bin Park, Yong-Chul Kim, Soo Hyun Eom   +6 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A Systems Science Approach to Sustainable Water Management in Rural Tourism Communities

Systems
In the face of the growing water crisis and current environmental pressures, rural communities with a tourism vocation face significant challenges in preserving their ecological and cultural integrity. These communities, whose livelihoods depend on their
Zeltzin Pérez-Matamoros, Ricardo Tejeida-Padilla, Isaías Badillo-Piña, Edgar Manuel Berdeja-Rocha   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Multilayer stretchable electronics with designs enabling a compact lateral form

npj Flexible Electronics
Stretchable electronics are of huge interest as they can be useful in various irregular non-planar or deformable surfaces including human bodies. High density multi-functional stretchable electronics are beneficial as they can be reliably used in more ...
Dongwuk Jung, Hunpyo Ju, Sungbum Cho, Taeyeon Lee, Changeui Hong, Jongho Lee   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

All-dielectric polarization-sensitive metasurface for terahertz polarimetric imaging

Scientific Reports
Terahertz polarimetric imaging, capable of capturing not only intensity profiles but also the polarization states of the incident pattern, is an essential technique with promising applications such as security scans and medical diagnoses.
Juhoon Baek, Jaehoon Kim, Jae Hun Seol, Minkyung Kim   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source