Results 111 to 120 of about 116,518 (256)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Desmoid-Type Fibromatosis of the Proximal Jejunum Mimicking Gastric Gastrointestinal Stromal Tumor: Diagnostic Pitfalls in Determining the Tumor Origin. [PDF]

Surg Case Rep
Ikeshita C, Nishibeppu K, Kosuga T, Sumiyoshi S, Inoue H, Kurashima K, Takabatake K, Kubo H, Kiuchi J, Imamura T, Nanishi K, Shimizu H, Arita T, Yamamoto Y, Konishi H, Morimura R, Fujiwara H, Shiozaki A.   +17 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Rapidly Progressive Gastric Poorly Differentiated Neuroendocrine Carcinoma Mimicking Gastrointestinal Stromal Tumor: A Case Report. [PDF]

Korean J Helicobacter Up Gastrointest Res
Choi Y.
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Dedifferentiated Gastric Gastrointestinal Stromal Tumor with Rapid Growth Mimicking Other Malignancies: A Case Report. [PDF]

Surg Case Rep
Iijima K, Takahashi T, Kurokawa Y, Saito T, Hagi T, Nakai S, Momose K, Yamashita K, Tanaka K, Makino T, Nakajima K, Genko Y, Kurashige M, Morii E, Eguchi H, Doki Y.   +15 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Transmural gastrointestinal stromal tumor of the mixed subtype in a canine: case report

Brazilian Journal of Veterinary Pathology
Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms originating from interstitial cells of Cajal, characterized, in most cases, by the immunohistochemical expression of c-Kit (CD117). In dogs, they are rare and the associated clinical signs
Lucas Costa Nogueira, Virgilio Zoppi Lemos, Luise Klawa Jubrael, Tábata Maués, Angélica Consalter, Marcela Freire Vallim de Mello   +5 more
doaj  

EPHA3, upregulated in high-risk histological subtypes of gastrointestinal stromal tumor, promotes GIST progression. [PDF]

Radiol Oncol
Wei H, Zhao J, Wang H, Guo L, Liu Y, Wang C, Yang L, Qi Z, Tian W, Cao L, Gao Y.   +10 more
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source