Results 21 to 30 of about 112,663 (257)

Emerging Data on the Safety and Efficacy of Ripretinib for the Treatment of Gastrointestinal Stromal Tumors

Clinical and Experimental Gastroenterology, 2023
Prapassorn Thirasastr, Neeta Somaiah Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence: Neeta Somaiah, Department of Sarcoma Medical Oncology, The University of Texas MD Anderson ...
Thirasastr P, Somaiah N
doaj  

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Fusion yield enhancement via secondary beam-target reactions in laser-cluster experiments

Scientific Reports
Laser-cluster fusion offers a unique compact platform for studying nuclear reactions in the sub-100 keV regime. Here we report the first experimental demonstration of secondary beam-target DD fusion reactions in laser-cluster fusion experiments by ...
Jun Sim, Seongmin Lee, Hyeong-il Kim, Youhwan Noh, Jaehyun Song, Chiwan Song, Junho Won, Woosuk Bang   +7 more
doaj   +1 more source

The Combined Effect of Obesity and Contraceptive Use on Pulmonary Embolism in Adolescent Females Residing in the United States

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Combined oral contraceptive (COC) use in obese adult women dramatically increases the relative risk of developing a pulmonary embolism (PE). The risk of a PE in obese adolescent females taking contraceptives is currently unknown. The purpose of this investigation was to determine the effect of body mass index (BMI) and contraceptive
John Puetz, Joanne Salas
wiley   +1 more source

Cryo-EM structure of cadmium-bound human ABCB6

Communications Biology
ATP-binding cassette transporter B6 (ABCB6), a protein essential for heme biosynthesis in mitochondria, also functions as a heavy metal efflux pump. Here, we present cryo-electron microscopy structures of human ABCB6 bound to a cadmium Cd(II) ion in the ...
Seung Hun Choi, Sang Soo Lee, Hyeon You Lee, Subin Kim, Ji Won Kim, Mi Sun Jin   +5 more
doaj   +1 more source

Why precision oncology works: lessons from gastrointestinal stromal tumours [PDF]

Exploration of Targeted Anti-tumor Therapy
Gastrointestinal stromal tumours (GISTs) are the clearest solid-tumour model of precision oncology because diagnosis, prognosis, and treatment are strongly shaped by molecular genotype. The discovery of activating mutations in KIT proto-oncogene receptor
Si Ying Adelina Ho, Alwyn Hong Sheng Tok, Hui Qi Megan Kimberly Han, Jens Samol, Vishal G Shelat   +4 more
doaj   +1 more source

Evaluation of the gastrointestinal stromal tumors for clinical features, histopathological findings and prognostic criteria: A case-control study

İstanbul Kuzey Klinikleri, 2020
OBJECTIVE: In this study, we reviewed GISTs with all morphological and immunohistochemical findings and assessed the prognostic parameters of these tumors.
Tolga Canbak, Baris Bayraktar, Aylin Acar, Rafet Yigitbasi   +3 more
doaj   +1 more source

Enhanced homeostatic sleep response and decreased neurodegenerative proteins in cereblon knock-out mice

Communications Biology
Energy homeostasis and sleep have a bidirectional relationship. Cereblon (CRBN) regulates energy levels by ubiquitinating the AMP-activated protein kinase(AMPK), an energy sensor. However, whether CRBN participates in sleep is unclear.
Jun-Hyung Jung, Jinhong Kim, Uroos Akber, Na Young Lee, Jeong-won Baek, Jieun Jung, Mincheol Park, Jiseung Kang, Seungje Jeon, Chul-Seung Park, Tae Kim   +10 more
doaj   +1 more source

Gastrointestinal stromal tumors: a focus on the impact of interstitial cells of Cajal in disease development

Journal of Mind and Medical Sciences
Introduction. Interstitial Cells of Cajal (ICCs) play a critical role in the regulation of gastrointestinal motility and have been implicated in various functional gastrointestinal disorders.
Petru Radu, Mihai Zurzu, Anca Tigora, Vlad Paic, Mircea Bratucu, Dragos Garofil, Valeriu Surlin, Stefan Patrascu, Virgiliu Prunoiu, Ionut Simion Coman, Valentin Georgescu, Razvan Daniel Chivu, Florian Popa, Victor Strambu, Raluca Gabriela Ioan   +14 more
doaj   +1 more source

A Surprise Visitor at Cesarean Section: Gastrointestinal Stromal Tumor of the Uterus

Middle East Journal of Cancer, 2020
Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors that almost always arise from the GI tract and account for 0.1-3% of GI tumors. During pregnancy, GIST is highly unusual given the predilection of this tumor to appear in the fifth to ...
Simon Raif Marcos, Bhanu Pratap Singh, Devesh Sanjeev Ballal, Faris Alaswad, Shakeel Akhtar, Gabriel Rodrigues   +5 more
doaj   +1 more source