Results 61 to 70 of about 725 (179)
From gene to disease; mutations in the SLC12A3 gene as the cause of Gitelman's syndrome [PDF]
, 2005 Gitelman's syndrome is characterised by persistent hypokalaemia, hypomagnesaemia and hypocalciuria (OMIM 263800). This rare autosomal recessive disorder is caused by renal Na+, Cl-, K+ and Mg2+ wasting. Other typical features include hypocalciuria and an
Bindels, R J M +3 more
core +2 more sources
Studies To Determine The Prevalence Of Candidate Gene Polymorphism For Hypertension Among Malays [PDF]
, 2007 Hipertensi atau peningkatan tekanan darah arteri adalah merupakan masalah kesihatan umum yang penting dan adalah merupakan faktor risiko yang utama bagi kebanyakkan kecacatan dan kematian kardiovaskular.
Mohd Ghazali, Dzuzaini
core
Regulatory control of the Na-Cl co-transporter NCC and its therapeutic potential for hypertension [PDF]
, 2020 This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.Hypertension is the largest risk factor for cardiovascular disease, the leading cause of mortality worldwide.
Koeners, MP, Meor Azlan, NF, Zhang, J
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Brain and Behavior, Volume 15, Issue 11, November 2025.This fMRI‐study investigated emotional processing in patients with early MS and in healthy controls. We found flattened emotional experience associated with increased functional connectivity and brain response in the DLPFC and amygdala in patients. This suggests a disease‐related adaptive upregulation of the emotion processing and regulation network in
Torsten Wüstenberg +5 more
wiley +1 more source
Familial Hypokalemic Alkalosis: Gitelman’s Syndrome
Turkish Journal of Nephrology, 2019 Gitelman’s syndrome is one of the major variant of familial hypokalemic alkalosis syndromes, presenting with hypocalciuria, hypomagnesemia, and sodium and cloride wasting, which results in hyperreninemia and hyperaldosteronism.
Mesut AKÇAKAYA +5 more
doaj
Animal models of hypertension and concurrent organs injury
Animal Models and Experimental Medicine, Volume 8, Issue 10, Page 1775-1784, October 2025.Although hypertension is a frequently seen chronic condition across the world, its exact cause remains unclear. Animal models are beneficial for clarifying the pathogenic mechanism of hypertension and examining new treatments. An optimal animal model for studies on hypertension must well mimic human‐like hemodynamics and pathophysiological structural ...
Ye Wang, Xiaoliang Jiang, Zhiwei Yang
wiley +1 more source
The WNK-SPAK/OSR1 kinases and the cation-chloride cotransporters as therapeutic targets for neurological diseases [PDF]
, 2019 This is the final version. Available on open access from Aging and Disease via the DOI in thei recordIn recent years, cation-chloride cotransporters (CCCs) have drawn attention in the medical neuroscience research.
Banerjee, S +7 more
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Veterinary Record Case Reports, Volume 13, Issue 3, September 2025.Abstract Renal potassium wasting syndromes, such as Gitelman's syndrome (GS), are well documented in humans but rarely reported in veterinary medicine. This case describes a 6‐month‐old domestic medium‐hair cat presenting with chronic hypokalaemia, polyuria and polydipsia. Diagnostic evaluation revealed hypokalaemia, metabolic alkalosis, hypochloraemia
Kyle L. Granger Jr. +2 more
wiley +1 more source
, 2018 Metabolic alkalosis is a disorder where the primary defect, an increase in plasma bicarbonate concentration, leads to an increase in systemic pH. Here we review the causes of metabolic alkalosis with an emphasis on the inherited causes, namely Gitelman ...
Mabillard, Holly, Sayer, John A.
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