Results 41 to 50 of about 1,230,526 (158)

Bushen Huatan Formula Ameliorates Early Chronic Low‐Grade Inflammation in Obese PCOS Via the TLR4/NF‐κB Signaling Pathway: An Integrated Network Pharmacology and Experimental Study

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Objective This study used an integrated network pharmacology and experimental strategy to investigate how Bushen Huatan Formula (BHF) mitigates early‐stage chronic low‐grade inflammation in obese polycystic ovary syndrome (PCOS). Methods Candidate components and targets of BHF were retrieved from the TCMSP database, and protein–protein ...
Jianing Zhang, Fangyun Gu, Yunyun Li, Xiaoling Feng, Hongying Kuang, Fang Xu, Miao Sun   +6 more
wiley   +1 more source

Bartter's and Gitelman's syndromes: from gene to clinic

, 2004
Bartter's and Gitelman's syndromes are characterized by hypokalemia, normal to low blood pressure and hypochloremic metabolic alkalosis. Recently, investigators have been able to demonstrate mutations of six genes encoding several renal tubular ...
Verberckmoes, René, STEELS, Paul, Vanrenterghem, Yves, Naesens, Maarten, Kuypers, Dirk   +4 more
core   +1 more source

Bartter and Gitelman syndromes: Questions of class [PDF]

Pediatric Nephrology, 2019
AbstractBartter and Gitelman syndromes are rare inherited tubulopathies characterized by hypokalaemic, hypochloraemic metabolic alkalosis. They are caused by mutations in at least 7 genes involved in the reabsorption of sodium in the thick ascending limb (TAL) of the loop of Henle and/or the distal convoluted tubule (DCT).
Martine T. P. Besouw, Robert Kleta, Detlef Bockenhauer   +2 more
openaire   +3 more sources

Reduced Expression of Magnesium Transport Proteins in the Distal Convoluted Tubule of Clcnkb‐Deficient Mice May Explain Urinary Magnesium Wasting in Classical Bartter Syndrome

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT Aim The kidney thick ascending limb (TAL) plays a key role in the transport of sodium, chloride, potassium, calcium, and magnesium. Bartter syndrome is a hypokalemic, salt‐losing tubulopathy caused by impaired TAL function. Pathogenic variants in SLC12A1 or KCNJ1 cause antenatal Bartter syndrome, and variants in CLCNKB result in classical ...
Marleen L. A. Kortenoeven, Milos Bogdanovic, Ida Appel, Karsten Skjødt, Ernst‐Martin Fuchtbauer, Kirsten Madsen, Lars Lund, Régine Chambrey, Dominique Eladari, R. Todd Alexander, Christian A. Hübner, J. Christopher Hennings, Henrik Dimke   +12 more
wiley   +1 more source

Urine electrolytes guide treatment of Gitelman syndrome and recurrent syncope—A case report

Physiological Reports, Volume 14, Issue 18, September 2026.
Abstract Syncope is a common reason for inpatient admission. Few case studies describe an association between syncope and Gitelman syndrome (GS). Herein, we present a case of a woman with hypokalemia and recurrent syncope which eventually led to a diagnosis of GS. A physiologic approach to urine electrolyte interpretation informed clinical decisions to
Saloni Agrawal, Kenneth M. Fifer, Samira S. Farouk, Joshua L. Rein   +3 more
wiley   +1 more source

Hypertension in a patient with Gitelman's syndrome [PDF]

Journal of Human Hypertension, 2004
Gitelman's syndrome is an autosomal recessive disorder characterized by sodium wasting and hypotension. A middle-aged woman was diagnosed with Gitelman's syndrome because of typical clinical manifestations in the youth and homozygous mutations of 18-base-pair insertion in exon 6 of thiazide-sensitive NaCl-cotransporter gene.
T, Ogihara, T, Katsuya, K, Ishikawa, A, Matsuo, H, Rakugi, M, Shoji, M, Yasujima   +6 more
openaire   +2 more sources

Generalized seizures as onset of Gitelman's syndrome

, 2009
Gitelman's syndrome is a rare autosomal recessive syndrome presenting with hypocalciuria, hypomagnesiemia and hypokalemic metabolic alkalosis.
Jeppesen, Eva Mosfeldt, Christiansen, Peter, Hvelplund, Carolina, Mortensen, Henrik B   +3 more
core   +1 more source

Gitelman's syndrome associated with chondrocalcinosis: a case report

, 2013
Gitelman's syndrome (GS) is a rare disease with autosomal recessive trait, characterized by hypokalemia, hypomagnesemia, metabolic alkalosis, hypocalciuria and hyperkinemic hyperaldosteronism.
Alaygut, Demet, Huzmeli, Can, Candan, Ferhan, Kockara, Ayse Seker, Kayatas, Mansur, EĞLENOĞLU ALAYGUT, DEMET, KOÇKARA, AYŞE   +6 more
core   +1 more source

Clinical implementation of digital cognitive assessments – recommendations from Global CEO Initiative on Alzheimer's Disease

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Mild cognitive impairment and dementia are underrecognized in primary care, contributing to delayed diagnosis and limited access to care. Growing research has focused on improving cognitive evaluation in primary care, including the development of digital cognitive assessments (DCAs), which are emerging as scalable tools to expand access to ...
Pierre N. Tariot, Darren R. Gitelman, Ishtar Govia, Katherine A. Partrick, Emily Scholler, Melissa Petersen, the CEOi Digital Cognitive Assessment Workgroup   +6 more
wiley   +1 more source

Home Parenteral Support in Severe Gitelman Syndrome: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Gitelman syndrome (GS), also known as familial hypokalaemia‐hypomagnesemia, is a rare autosomal recessive renal tubular disorder characterized by hypokalaemia, hypomagnesemia, metabolic alkalosis, and hypocalciuria. Electrolyte replacement of potassium and magnesium remains the mainstay of management, with oral supplementation achieving this ...
Georgia Martin, Ibrahim Fahal, Shameer Mehta   +2 more
wiley   +1 more source