Results 31 to 40 of about 1,221,013 (139)

Dapagliflozin Attenuates NKCC2 Protein Expression and Alleviates Diabetic Kidney Disease in Salt Loaded‐Hypertensive Diabetic Db/Db Mice

FASEB BioAdvances, Volume 8, Issue 10, October 2026.
In salt‐loaded, hypertensive diabetic db/db mice with diabetic kidney disease, dapagliflozin lowered blood pressure and reduced tubular and glomerular injury. Mechanistically, dapagliflozin increased cullin E3 ligase abundance, promoting degradation of NKCC2.
Zenab Shahzad, Niharika Bala, Arooba Illyas, Amir Kazory, Indra Chandrasekar, Abdel A. Alli   +5 more
wiley   +1 more source

Nucleic Acids as Emerging Regulators of Calcium Phosphate Biomineralization

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Calcium phosphate biomineralization has traditionally been considered a protein‐regulated process. This review highlights the emerging role of nucleic acids, which interact with mineral phases through adsorption, coprecipitation, and templating, thereby influencing crystal nucleation and growth.
Fanny Duhalde, Jessem Landoulsi, Xavier Houard   +2 more
wiley   +1 more source

Arg913Gln variation of SLC12A3 gene is associated with diabetic nephropathy in type 2 diabetes and Gitelman syndrome: a systematic review

BMC Nephrology, 2019
Background Diabetic nephropathy is a global common cause of chronic kidney disease and end-stage renal disease. A lot of research has been conducted in biomedical sciences, which has enhanced understanding of the pathophysiology of diabetic nephropathy ...
Eduardo De la Cruz-Cano, Cristina del C. Jiménez-González, Vicente Morales-García, Conny Pineda-Pérez, Juan G. Tejas-Juárez, Francisco J. Rendón-Gandarilla, Silvia Jiménez-Morales, José A. Díaz-Gandarilla   +7 more
doaj   +1 more source

Gαq/p63RhoGEF interaction in RhoA/Rho kinase signaling: investigation in Gitelman’s syndrome and implications with hypertension

, 2017
Purpose: Gitelman’s syndrome (GS) presents normo-hypotension and absence of cardiovascular–renal remodeling despite high angiotensin II (Ang II), activation of renin–angiotensin–aldosterone system and is a human model of endogenous antagonism of Ang II ...
NASO, ELENA, V. Ravarotto, G. Maiolino, RAVAROTTO, VERDIANA, MAIOLINO, GIUSEPPE, E. Naso, CALO', LORENZO, PAGNIN, ELISA, P. A. Davis, Davis, Pa, L. A. Calò, E. Pagnin   +11 more
core   +1 more source

Bartter Syndrome With Normal Aldosterone Level and Acute Pancreatitis: An Unusual Presentation

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Bartter syndrome is a rare autosomal recessive renal tubulopathy, which classically presents with hypokalemic metabolic alkalosis, hyperreninemia, and hyperaldosteronism. We report an atypical presentation in a 16‐year‐old male who was diagnosed following an initial manifestation of acute pancreatitis.
Noor Ayaz, Matti Ullah, Waqar Ahmad, Farhan Ullah, Ikram Ullah Khan, Fahad Naim, Awais Naeem, Fatima Sajjad, Kamil Ahmad Kamil   +8 more
wiley   +1 more source

Prevalence of the metabolic syndrome in Chinese adolescents [PDF]

, 2008
Since national figures on the occurrence of metabolic syndrome among Chinese adolescents are lacking, this study aims to estimate its prevalence and distribution among Chinese youngsters.
Yang, X., Kok, F.J., Zhai, F., Li, Y., Piao, J., Zhang, J., Ma, G.   +6 more
core   +1 more source

Bushen Huatan Formula Ameliorates Early Chronic Low‐Grade Inflammation in Obese PCOS Via the TLR4/NF‐κB Signaling Pathway: An Integrated Network Pharmacology and Experimental Study

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Objective This study used an integrated network pharmacology and experimental strategy to investigate how Bushen Huatan Formula (BHF) mitigates early‐stage chronic low‐grade inflammation in obese polycystic ovary syndrome (PCOS). Methods Candidate components and targets of BHF were retrieved from the TCMSP database, and protein–protein ...
Jianing Zhang, Fangyun Gu, Yunyun Li, Xiaoling Feng, Hongying Kuang, Fang Xu, Miao Sun   +6 more
wiley   +1 more source

Reduced Expression of Magnesium Transport Proteins in the Distal Convoluted Tubule of Clcnkb‐Deficient Mice May Explain Urinary Magnesium Wasting in Classical Bartter Syndrome

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT Aim The kidney thick ascending limb (TAL) plays a key role in the transport of sodium, chloride, potassium, calcium, and magnesium. Bartter syndrome is a hypokalemic, salt‐losing tubulopathy caused by impaired TAL function. Pathogenic variants in SLC12A1 or KCNJ1 cause antenatal Bartter syndrome, and variants in CLCNKB result in classical ...
Marleen L. A. Kortenoeven, Milos Bogdanovic, Ida Appel, Karsten Skjødt, Ernst‐Martin Fuchtbauer, Kirsten Madsen, Lars Lund, Régine Chambrey, Dominique Eladari, R. Todd Alexander, Christian A. Hübner, J. Christopher Hennings, Henrik Dimke   +12 more
wiley   +1 more source

Pathophysiology of Post Transplant Hypertension in Kidney Transplant: Focus on Calcineurin Inhibitors Induced Oxidative Stress and Renal Sodium Retention and Implications with RhoA/Rho Kinase Pathway

Kidney & Blood Pressure Research, 2017
Post-transplant hypertension is a common occurrence during treatment with calcineurin inhibitors (CNIs) in kidney transplant population. The pathogenesis of vasoconstriction induced by CNIs involves vascular tone alterations and kidney sodium transport ...
Lorenzo A. Calò, Verdiana Ravarotto, Francesca Simioni, Elena Naso, Francesco Marchini, Luciana Bonfante, Lucrezia Furian, Paolo Rigotti   +7 more
doaj   +1 more source

Gitelman's Syndrome: characterization of a novel c.1181G>A point mutation and functional classification of the known mutations.

, 2018
We have investigated the mechanisms by which a novel missense point mutation (c.1181G>A) found in two sisters causes Gitelman’s syndrome by impairing the sodium chloride co-transporter (NCC, encoded by SLC12A3 gene) function.
Calò LA, Rossi, Gian Paolo, Dominique Loffing-Cueni, Michèle Heidemeyer, Gian Paolo Rossi, Loffing-Cueni D, Rossi GP, Pagnin, Elisa, Ravarotto, Verdiana, Lorenzo A. Calò, Loffing J, Verdiana Ravarotto, Elisa Pagnin, Calò, Lorenzo A, Ravarotto V, Heidemeyer M, Loffing, Johannes, Heidemeyer, Michèle, Loffing-Cueni, Dominique, Pagnin E, Johannes Loffing   +20 more
core   +1 more source