Results 41 to 50 of about 122,064 (264)
Always in the Field: Introducing the WebDig App
Internet ArchaeologyAmongst the digital tools that projects use to gather data in the field, an application created for use in the Athenian Agora excavations has gained traction in recent decades: iDig.
Nathan T. Arrington +3 more
doaj +1 more source
Cataloging GitHub Repositories
Proceedings of the 21st International Conference on Evaluation and Assessment in Software Engineering, 2017 GitHub is one of the largest and most popular repository hosting service today, having about 14 million users and more than 54 million repositories as of March 2017. This makes it an excellent platform to find projects that developers are interested in exploring.
Abhishek Sharma 0002 +4 more
openaire +3 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
A Mamdani FIS to Monitor Programmer Performance on GitHub
IJCCS (Indonesian Journal of Computing and Cybernetics Systems)A collaborative activity used to accomplish shared objectives is teamwork. It is essential to know how unequal contributions can inhibit team members' chances to give their all in achieving these objectives.
Susi Eva Maria Purba, Retantyo Wardoyo
doaj +1 more source
EPJ Data Science, 2022 GitHub has become the central online platform for much of open source, hosting most open source code repositories. With this popularity, the public digital traces of GitHub are now a valuable means to study teamwork and collaboration.
Milo Z. Trujillo +2 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Methods in Ecology and Evolution, 2023 Researchers in ecology and evolutionary biology are increasingly dependent on computational code to conduct research. Hence, the use of efficient methods to share, reproduce, and collaborate on code as well as document research is fundamental.
Pedro Henrique Pereira Braga +16 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source