Results 51 to 60 of about 122,064 (264)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A Comparative Analysis of the Use of GitHub by Librarians and Non-Librarians

Evidence Based Library and Information Practice, 2018
Objective – GitHub is a popular tool that allows software developers to collaborate and share their code on the web. Librarians have adopted GitHub to support their own work, sharing code in support of their libraries.
Mark Edward Eaton
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Building a static website with Jekyll and GitHub Pages

The Programming Historian, 2016
This lesson is for you if you’d like an entirely free, easy-to-maintain, preservation-friendly, secure website over which you have full control, such as a scholarly blog, project website, or online portfolio.
Amanda Visconti
doaj  

GitHub Hierarchical Learning and Retrieval Service Based on Knowledge Graphs [PDF]

Jisuanji gongcheng
As the largest online code hosting platform in the world, GitHub provides rich learning resources for software development learners. However, faced with such rich and complex GitHub content, beginners in software development often encounter difficulties ...
JIANG Huizhen, SUN Yanchun, HUANG Gang
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Learning Web Development using GitHub Copilot in and outside Academia: a Blessing or a Curse? [PDF]

Interdisciplinary Description of Complex Systems
This article investigates the usage of GitHub Copilot, an artificial intelligence-powered coding assistant owned by Microsoft and GitHub, in the process of learning and teaching web development both in formal academic, and informal settings. We dive into
Gabriel Oliver Mesaroš
doaj   +1 more source

GitHub Visualizations and their Usefulness for GitHub Users

, 2020
Det mest populära versionshanteringssystemet är utan tvekan Git, för vilket GitHub med sina 40 miljoner användare ger en central plats där Git-repos kan utforskas och bidras till. Med all metadata som Git-repos innehåller, har GitHub också en betydande mängd data i sina 44 miljoner repos som kan nås fritt med GitHub API. För att utnyttja denna data har
Sahlin, Daniel, Stjernberg, Christian
openaire   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source