Results 141 to 150 of about 3,305,571 (308)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

open access: yesFEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Give Us This Day - ACE120.2

open access: yes
Caption: "My father only ever had two books, one was the Bible, the other was The Ragged Trousered Philanthropists." "Robert Tressell" writing. VO: "In writing this book my intention was to present, in the form of an interesting story, a faithful ...

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Felice Battaglia, Metafisica, religione e politico nel pensiero di Nicolà da Cusa

open access: yes, 1967
de Give Michel. Felice Battaglia, Metafisica, religione e politico nel pensiero di Nicolà da Cusa. In: Revue Philosophique de Louvain. Troisième série, tome 65, n°85, 1967. pp.
de Give, Michel
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Development of a Direct-to-Biology Platform to Discover Potent MNK Inhibitors. [PDF]

open access: yesJ Med Chem
Vagadia PP   +5 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Give Us This Day - ACE120.4

open access: yes
Workmen on break wondering what they might do about Tom’s dismissal. Noonan says that they join the Society to protect themselves, and tells his co-workers that a non-working majority prospers while the poor workers starve.

core  

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