Results 231 to 240 of about 11,157,351 (306)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Synthesis, antioxidant and antimicrobial activities, molecular docking study of new pyrimidine derivatives. [PDF]

Sci Rep
Khalaf HS, El-Rashedy AA, Abd El-Gwaad AA, Fayed AA.   +3 more
europepmc   +1 more source

Should Norway give up regional employment subsidies? [PDF]

Ostbye, Stein
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Synthesis of some novel coumarin-based heterocycles, elucidation of their antifungal behavior, molecular docking and computational studies. [PDF]

Sci Rep
Ismail MF, Salem MAI, Marzouk MI, Mahmoud NFH, Abdullah NH, Gouda MAS.   +5 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Looking Under the Hood: Using Time-Frequency Analysis to Bridge the Gap Between Event-Related Potential Biomarkers of Psychosis and Underlying Neural Circuitry. [PDF]

Biol Psychiatry Glob Open Sci
Erickson MA.
europepmc   +1 more source

Protein Structure Determination by Racemic and Quasi-Racemic X-Ray Crystallography. [PDF]

Chembiochem
Kent SBH.
europepmc   +1 more source

Quality Assurance and Educational Guidelines for an Emergency Medical Preparatory Programme in South Africa: A Qualitative Case Study. [PDF]

Health Sci Rep
Nell EN, Jama MP, Du Plessis JG.
europepmc   +1 more source

Roles and Responsibilities in Pharmacy Practice as Determinants of Burnout: A Comparative Cross-Sectional Survey of Community Pharmacists and Pharmacy Assistants in the Northeastern Region of Bulgaria. [PDF]

Pharmacy (Basel)
Ivanova M, Tsvetkova A, Todorova A.
europepmc   +1 more source