Results 201 to 210 of about 1,496,082 (264)

Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO. [PDF]

Cell Chem Biol
Lindsey GL, Hockley TK, Gomez AV, Marshall AC, Brothers WR, Finney CT, Gross J, Fox AH, Yeo GW, Melillo B, Bond CS, Cravatt BF.   +11 more
europepmc   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Performance Improvement of the Acrylic Acid-Polyvinyl Alcohol Gel Dosimeter with an Organic Additive for Radiation Oncology Applications. [PDF]

Gels
Moftah B, Rabaeh KA, Moussa AA, Bani Issa AS, Al Kafi MA.   +4 more
europepmc   +1 more source

The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo

Advanced Science, EarlyView.
We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge, María Pagnon de la Vega, Silvia Zampar, Enrica Cerilli, Srinivas Koutarapu, Ling Wu, Paul Fraser, Sertan Arkan, Vilmantas Giedraitis, Lars Lannfelt, Greta Hultqvist, Stina Syvänen, Martin Ingelsson, Jörg Hanrieder, Dag Sehlin   +14 more
wiley   +1 more source

Mechanical loading and fatigue-induced changes in triceps surae muscle-tendon unit: sex-specific responses and recovery dynamics. [PDF]

Front Physiol
Salatkaitė-Urbonė S, Lasevičius R, Wezenbeek E, Satkunskienė D.   +3 more
europepmc   +1 more source

Allogeneic Immune Cell Perfusion Inhibits the Growth of Vascularized 3D In Vitro Tumor Models, Induces Vascular Regression and Desmoplasia, but Promotes Tumor Cell Invasion

Advanced Science, EarlyView.
This study presents a vascularized 3D tumor model to investigate immune–stromal–tumor interactions under allogeneic PBMC perfusion. While immune cells induced tumor shrinkage, they also promoted vascular regression, stromal activation, and cancer cell invasion.
Alexandra Raab, Rasika Daware, Marcelo A. Szymanski de Toledo, Oskar Weber, Dimitris Kapsokalyvas, Twan Lammers, Horst Fischer, Federica De Lorenzi, Fabian Kiessling   +8 more
wiley   +1 more source

Decoding Hydrogen-Bond Network of Electrolyte for Cryogenic Durable Aqueous Zinc-Ion Batteries. [PDF]

Nanomicro Lett
Wei X, Guan J, Mu Y, Zou Y, Wei X, Yang L, Man Q, Yang C, Zang L, Sun J, Zeng L.   +10 more
europepmc   +1 more source

The Role of Ionic Liquids at the Biological Interfaces in Bioelectronics

Advanced Science, EarlyView.
Ionic liquids (ILs) are highlighted as key artificial ionic materials that bridge biological ion‐based signaling and electronic devices. By understanding their composition, structure, function relationships, and mechanisms, ILs can advance from high performance electrolyte to core materials enabling integrated, multifunctional bioelectronics for ...
Yeong‐sinn Ye, Young Jin Jo, Ji Yeon Oh, Ju Yeon Jeong, Lili Guo, Tae‐il Kim   +5 more
wiley   +1 more source

Automatic Identification of Lower-Limb Neuromuscular Activation Patterns During Gait Using a Textile Wearable Multisensor System. [PDF]

Sensors (Basel)
Amitrano F, Coccia A, Colelli Riano F, Pagano G, Biancardi A, Losavio E, D'Addio G.   +6 more
europepmc   +1 more source