Natural Hazards ResearchThe study aimed to investigate the potential glacial lakes in response to climate change and the associated risk of glacial lake outburst floods (GLOFs).
Mariam Sarwar, Shakeel Mahmood
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman +9 more
wiley +1 more source
Indian monsoon variability on millennial-orbital timescales [PDF]
, 2016 The Indian summer monsoon (ISM) monsoon is critical to billions of people living in the region. Yet, significant debates remain on primary ISM drivers on millennial-orbital timescales.
Breitenbach, Sebastian +11 more
core +3 more sources
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Integrated Summer Insolation Forcing and 40,000-Year Glacial Cycles: The Perspective from an Ice-Sheet/Energy-Balance Model [PDF]
, 2008 Although the origins of the 40,000-year glacial cycles during the early Pleistocene are readily attributed to changes in Earth's obliquity (also having a 40,000-year period), the lack of ice-volume variability at precession periods (20,000 years) is ...
Huybers, Peter, Tziperman, Eli
core +1 more source
The spatiotemporal extent of the Green Sahara during the last glacial period. [PDF]
iScience, 2023 Ait Brahim Y +6 more
europepmc +1 more source
The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp +4 more
wiley +1 more source
Dynamics between order and chaos in conceptual models of glacial cycles
, 2013 The dynamics of glacial cycles is studied in terms of the dynamical systems theory. We explore the dependence of the climate state on the phase of astronomical forcing by examining five conceptual models of glacial cycles proposed in the literature.
Aihara, Kazuyuki, Mitsui, Takahito
core +1 more source
Modeling of the northern hemisphere ice sheets during the last glacial cycle and glaciological sensitivity [PDF]
, 2005 We present a new three-dimensional thermomechanically coupled ice sheet model of the northern hemisphere to reconstruct the Quaternary ice sheets during the last glacial cycle.
Huybrechts, Philippe, Zweck, C.
core +1 more source
Antiphase response of the Indonesian-Australian monsoon to millennial-scale events of the last glacial period. [PDF]
Sci Rep, 2022 Scroxton N +9 more
europepmc +1 more source