Results 71 to 80 of about 1,357,505 (322)
Advanced Science, EarlyView.This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo +17 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Rapid mass loss of glaciers in High Mountain Asia has large consequences for downstream water supply and glacier-related hazards. Glaciers in the southeastern Tibetan Plateau are experiencing the highest mass loss rates within Asia, despite ...
A. Jouberton +8 more
semanticscholar +1 more source
The distribution of basal motion beneath a High Arctic polythermal glacier [PDF]
, 2003 The longitudinal pattern of surface velocity of a large, predominantly colds polythermal glacier (John Evans Glacier, Ellesmere Island, Canada) was measured over summer and winter periods.
Nienow, Peter W. +12 more
core +1 more source
Advanced Science, EarlyView.During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang +8 more
wiley +1 more source
Journal of Glaciology, 2019 Donjek Glacier has an unusually short and regular surge cycle, with eight surges identified since 1935 from aerial photographs and satellite imagery with a ~12 year repeat interval and ~2 year active phase.
WILLIAM KOCHTITZKY +6 more
doaj +1 more source
A physically based calving model applied to marine outlet glaciers and implications for the glacier dynamics [PDF]
, 2010 We present results from numerical ice-flow models that include calving criteria based on penetration of surface and basal crevasses, which in turn is a function of longitudinal strain rates near the glacier front.
Vieli, Andreas +22 more
core +2 more sources
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Groundwater Rise Sustains the World's Largest Alpine Water System Under Global Warming
Advanced Science, EarlyView.Shallow groundwater depth (SGWD) across the non‐permafrost plains of the Qinghai–Xizang Plateau decreased at averagely 0.02 m year−1, adding 31.44 Gt of freshwater storage from 2000 to 2020 and sustaining ∼53 500 km2 of alpine ecosystems. A vadose‐zone capacity of 426.6 Gt reveals these aquifers as promising reservoirs, highlighting groundwater's ...
Jianqing Du +15 more
wiley +1 more source
Glaciological results of the 2005 expedition to Inylchek Glacier, Central Tian Shan [PDF]
, 2008 Like many other glaciers in Central Asia, Southern Inylchek glacier in the Kyrgyz Tian Shan is covered by supraglacial moraine, which drastically influences melt rates and complicates the estimation of ablation. The quantification of sub-debris melt from
Lambrecht, Astrid +4 more
core +1 more source
Advanced Science, EarlyView.Polymer‐based hydrogels have emerged as promising materials for atmospheric water harvesting (AWH) due to their high water affinity, tunable network structure, and excellent moisture adsorption‐desorption performance. Functional hydrogel systems enable efficient water capture and controlled release under low‐energy conditions, offering a sustainable ...
Swagata Datta +6 more
wiley +1 more source