Results 61 to 70 of about 23,751,482 (337)

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, EarlyView.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

Landslide-generated tsunami and particle transport in mountain lakes and reservoirs

Annals of Glaciology, 2016
Gravitational mass flows may generate tsunamis as they hit water bodies such as oceans, reservoirs or mountain lakes. Upon impact, they can generate tremendous particle-laden or debris flows and floods.
Jeevan Kafle, Puskar R. Pokhrel, Khim B. Khattri, Parameshwari Kattel, Bhadra Man Tuladhar, Shiva P. Pudasaini   +5 more
doaj   +1 more source

Chloroplast Stress Signals Orchestrate Epidermis‐Specific Remodeling of Mitochondria and ER Under High Light

Advanced Science, EarlyView.
High light exposure triggers an epidermis‐specific remodeling of mitochondria and ER in Arabidopsis, driven by chloroplast‐derived signals. Live‐cell imaging shows that HL rapidly suppresses mitochondrial motility, followed by fusion‐driven elongation and ER cisternal expansion.
Evan R. Angelos, Hee‐Seung Choi, Jingzhe Guo, Andrea A. Zanini, Tessa M. Burch‐Smith, Emily Snyder, Matthew Part, Wilhelmina van de Ven, Manhoi Hur, Gerd Ulrich Balcke, Alain Tissier, Quanqing Zhang, Katayoon Dehesh   +12 more
wiley   +1 more source

A geophysical and glaciological survey of the highest tropical mountain glaciers (Mt. Huascarán, Andes)

Journal of Glaciology
Peru hosts a significant portion of the world’s tropical glaciers, which are undergoing rapid mass loss due to climate change. Knowledge of the ice volume and bedrock topography of these glaciers is important for predicting changes in glacier dynamics ...
Stanislav Kutuzov, Lonnie G. Thompson, John F. Bolzan, Ivan Lavrentiev, Gleb Chernyakov, Forrest Schoessow   +5 more
doaj   +1 more source

Modelling Glaciers in the HARMONIE-AROME NWP model [PDF]

Advances in Science and Research, 2017
Abstract. HARMONIE-AROME is a convection-permitting non-hydrostatic model that includes the multi-purpose SURFEX surface model. It is developed for high resolution (1–3 km) weather forecasting and applied in a number of regions in Europe and the Mediterranean. A version of HARMONIE-AROME is also under development for regional climate modelling. Here we
Ruth Mottram, Kristian Pagh Nielsen, Emily Gleeson, Xiaohua Yang   +3 more
openaire   +4 more sources

The Open Global Glacier Model (OGGM) v1.1

Geoscientific Model Development, 2019
. Despite their importance for sea-level rise, seasonal water availability, and as a source of geohazards, mountain glaciers are one of the few remaining subsystems of the global climate system for which no globally applicable, open source, community ...
F. Maussion, A. Butenko, N. Champollion, Matthias Dusch, Julia Eis, Kévin Fourteau, Philipp Gregor, A. Jarosch, J. Landmann, Felix Oesterle, Beatriz Recinos, Timo Rothenpieler, A. Vlug, C. Wild, B. Marzeion   +14 more
semanticscholar   +1 more source

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

Advanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He, Anqi Zhang, Zhanchen Guo, Qi Li, Song Gao, Wenyan Guan, Ying Li, Jingran Chen, Sijia Sun, Jian He, Zhen Liu   +10 more
wiley   +1 more source

Modelling Dynamics of Valley Glaciers

, 2012
Ever since the Paleoproterozoic snowball Earth era, ca. 2.4 billion years ago (e.g. Hoffman & Schrag, 2000; Kirschvink, 1992), and beyond, the landscape of the planet Earth has been shaped up by the tremendous amount of scouring due to the repeated waxing and waning of ice masses.
Adhikari, Surendra, Marshall, Shawn J.
openaire   +3 more sources

Subaqueous melting of Store Glacier, west Greenland from three‐dimensional, high‐resolution numerical modeling and ocean observations

Geophysical Research Letters, 2013
We present three‐dimensional, high‐resolution simulations of ice melting at the calving face of Store Glacier, a tidewater glacier in West Greenland, using the Massachusetts Institute of Technology general circulation model.
Yun Xu, E. Rignot, I. Fenty, D. Menemenlis, M. Flexas   +4 more
semanticscholar   +1 more source

Natural Negative Feedback Loops Confer Indica‐Japonica Differentiation for Grain Size Homeostasis in Rice

Advanced Science, EarlyView.
This study reveals the genetic and molecular mechanisms controlling grain size homeostasis through fine‐tuning OsGRX8 self‐expression by two natural negative feedback loops functioning in redox‐dependent or ‐independent manners and identifies two self‐regulatory haplotypes (SRHs) for the subspecies differentiation in rice.
Xingxing Li, Meng‐en Wu, Ziqi Qiao, Junkui Huang, Juncheng Zhang, Yang Ding, Junqing Zhu, Jingyue Xu, Yuxin Huang, Wei Li, Xiaomin Su, Yue Ding, Jianwei Zhang, Yibo Li   +13 more
wiley   +1 more source