Results 101 to 110 of about 1,741 (266)

New techniques for old bones: Morphometric and diffeomorphometric analysis of the bony labyrinth of the Reilingen and Ehringsdorf Neandertals

The Anatomical Record, EarlyView.
Abstract Neandertals are known to possess very distinctive traits in their bony labyrinth morphology, such as an inferiorly positioned posterior canal and a very low number of turns in the cochlea. Hence, the inner ear has been often used to assess the Neandertal status of fragmentary fossils.
Alessandro Urciuoli, Julia Diez‐Valero, Ignacio Martínez, Rolf Quam, Brian A. Keeling, Nicole M. Webb, Mercedes Conde‐Valverde   +6 more
wiley   +1 more source

Magnetoelastic Cell Monitoring System for Evaluating the Effects of Surface Chemistry on the Performance of Mesenchymal Stem Cell Growth

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The recent clinical adoption of cell therapies has increased the need for more efficient, robust, and reproducible manufacturing technologies. Human mesenchymal stromal cells (hMSCs), a major component of the cell and immunotherapeutic market, remain challenging to manufacture at scale because they require surface attachment and are highly ...
William S. Skinner, Carolina Rivera‐Crespo, Eyerusalem A. Gebreyesus, Said Cifuentes, Samantha Tan, Tristen Douglas, Maribella Domenech‐Garcia, Keat Ghee Ong   +7 more
wiley   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Tailoring drug‐to‐lipid ratio in redox‐responsive lipid‐mimetic prodrug liposomes for superior cabazitaxel delivery and antitumor efficacy

BMEMat, EarlyView.
Redox‐responsive lipid‐mimetic prodrug liposomes with high drug‐to‐lipid ratios enhance cabazitaxel delivery, prolong circulation, and enable tumor‐selective drug release for superior antitumor efficacy and safety. Abstract Liposomes represent one of the most extensively investigated nanocarriers in drug delivery.
Shengyao Xu, Danping Wang, Si Zheng, Zhiyu Kuang, Ya Gao, Haiyu Zhao, Lurong Zhang, Jiayu Guo, Jingyi Zhang, Weiyao Li, Anhua Wang, Hongrui Lei, Zhonggui He, Ken‐ichiro Kamei, Jianzhao Niu, Lingyun Ma, Bingjun Sun   +16 more
wiley   +1 more source

Nacre‐inspired layered composite with excellent mechanical support and osteogenic potential for cervical interbody cage

BMEMat, EarlyView.
The cervical interbody cage needs to take both biomechanical and biological requirements into account. Here, a new‐style degradable, multicomponent, and bioinspired nacre‐like cervical interbody cage composite, which exhibits promising mechanical‐support‐related behavior and osteogenesis‐related potential, is designed and prepared.
Xiu‐Wu Guo, Shao‐Meng Wen, Tian‐Yu Xing, Yang Zhou, Chun‐Xin Wang, Chang Ge, Si‐Ming Chen, Wen‐Zhi Zhang, Shu‐Hong Yu   +8 more
wiley   +1 more source

Advances in modelling of valley glaciers

, 2012
For glaciological conditions typical of valley glaciers, the central idea of this research lies in understanding the effects of high-order mechanics and parameterizing these for simpler dynamical and statistical methods in glaciology. As an effective tool for this, I formulate a new brand of dynamical models that describes distinct physical processes ...
openaire   +2 more sources

Evidence for adaptive explanations of semelparity in animals

Biological Reviews, EarlyView.
ABSTRACT Semelparity, the reproductive strategy of reproducing once, is widespread but uncommon in animals. Classes of models to explain the evolution of semelparity are based either on age structure and mortality schedules – demographic models in which high post‐reproductive mortality risk favours high reproductive effort and semelparity results from ...
Diana O. Fisher, Roberto Salguero‐Gómez   +1 more
wiley   +1 more source

Land birds on atolls: diversity, origin, and function

Biological Reviews, EarlyView.
ABSTRACT Oceanic islands are global hotspots of avian biodiversity and endemism. Their isolation and distinct environmental conditions have uniquely shaped the evolutionary trajectories of island birds, while, in turn, land bird communities have become critical providers of ecological functions to island ecosystems.
Sebastian Steibl, Alex S. Wegmann, Nick D. Holmes, Caitlin E. Andrews, Gérard Rocamora, Simon Ducatez, James C. Russell   +6 more
wiley   +1 more source

Hot and cold deserts as eco‐evolutionary arenas for understanding plant resistance to multiple abiotic stressors

Biological Reviews, EarlyView.
ABSTRACT During their long evolutionary history, land plants have evolved a range of adaptations to different abiotic stressors. These help explain present‐day diversity and distribution patterns, as well as the potential resilience of natural and agricultural systems to a changing climate. Most previous research has focused on adaptation to individual
Marc Fradera‐Soler, Natasha Barbolini, Anže Žerdoner Čalasan, Marian Schubert, Catarina Rydin, Olwen M. Grace, Aelys M. Humphreys   +6 more
wiley   +1 more source

Does Climate Risk Affect Employment Decisions? International Evidence

Business Strategy and the Environment, EarlyView.
ABSTRACT This study investigates the effect of climate risk on corporate employment decisions. Using a large sample from 41 countries, we find a positive association between climate risk and underinvestment in labor, notably manifesting as excessive employee layoffs.
Claude Francoeur, Faten Lakhal, Hamza Nizar, Zvi Singer   +3 more
wiley   +1 more source