Results 121 to 130 of about 1,674,137 (304)

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

First Alps-wide reconstruction of LGM glacial sediment transport enabled by GPU-accelerated particle tracking [PDF]

Earth Surface Dynamics
Reconstructing the transport histories and provenances of glacial sediments and ice-contact deposits (e.g. tills, moraines) in formerly glaciated regions remains a major challenge, particularly at icefield- to ice-sheet scales and over multi-millennial ...
T. P. M. Leger, G. Jouvet, S. Kamleitner, S. Kamleitner, B. D. Finley, M. Bernard, B. Allegri, F. Herman, A. Vieli, A. Henz, S. U. Nussbaumer   +10 more
doaj   +1 more source

SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition

Advanced Science, EarlyView.
The SEC promotes cell identity transitions by facilitating transcription pause release at key identity‐associated genes, including Klf4 and Myc during iPSC reprogramming and Nes and Tubb3 during ESC‐to‐neuroectodermal differentiation. During early iPSC reprogramming, this function additionally involves cooperation with METTL3‐associated m6A regulation.
Zhijing Zhang, Jingyi Xu, Yonghong Wu, Yitong Qu, Xinglin Hu, Yuchen Sun, Yanshuang Wu, Zhonghua Liu, Jiaqiang Wang, Lei Lei   +9 more
wiley   +1 more source

Engineering Spatially Localized Bioactive Microenvironments in Assembly Implants for Spatially Extended Bone Ingrowth

Advanced Science, EarlyView.
An assembly porous titanium/β‐TCP implant is developed to establish a spatially programmable osteogenic microenvironment for enhanced osseointegration. By decoupling mechanical support from bioactive ion release, localized ionic gradients generated from the β‐TCP module direct osteogenic activity and bone ingrowth toward the porous titanium framework ...
Heng Zhang, Jingjing Diao, Junhua Ke, Naru Zhao, Yudi Kuang, Yingjun Wang   +5 more
wiley   +1 more source

The impact of supraglacial ice cliff and pond formation on debris-free, tropical glacier mass loss

Journal of Glaciology
Tropical Andean glaciers provide an important flux of freshwater to communities living both in high-altitude Cordillera and population centres downstream in countries such as Peru and Bolivia. Glacier recession threatens the sustainability of these water
Owen King, Nilton Montoya, Bethan J. Davies, Tom Matthews, Miguel Vargas, Sajid Ghuffar, Tom Gribbin, Baker Perry, Maxwell Rado, Robert McNabb, Lindsey Nicholson, Jeremy Ely   +11 more
doaj   +1 more source

Assessing glacier retreat and landform production at the ‘debris-charged’ snout of Kvíárjökull, Iceland [PDF]

, 2010
Iceland is a critical location for the study of glacier fluctuations and landform production in response to climate change due to its diverse glacial legacy and its archive of aerial photographs that provide accurately dated records of glacier retreat ...
BENNETT, GEORGINA,LUCY
core  

LigHTS: Biomimetic Hydrogel Photo‐Fabrication for Imaging‐Based Ultra‐High‐Throughput Screening

Advanced Science, EarlyView.
LigHTS removes a key bottleneck for ultra‐high‐throughput screening (UHTS) by enabling biomimetic hydrogel microenvironments to be manufactured directly in standard multiwell plates. A single, collimated UV exposure with formulation‐tuned light penetration patterns an entire plate with UHTS‐grade uniformity (<20% CV), producing structured GelMA films ...
Alessandro Enrico, Sara Rigolli, Julius Zimmermann, Melissa Pezzotti, Eloisa Torchia, Moises Di Sante, Ferdinando Auricchio, Francesco S. Pasqualini   +7 more
wiley   +1 more source

Minimal Glacier Models

, 2008
During the past few decades the study of glaciers and their response to climate change has shown a strong development. Early theoretical work in the fifties and sixties has been complemented by the construction of numerical models of glaciers and ice sheets with various degrees of complexity.
openaire   +3 more sources

Glacier Image Velocimetry (GIV)

, 2020
Glacier Image Velocimetry (GIV) toolbox release to accompany the submission of Van Wyk de Vries and Wickert (2020), Glacier Image Velocimetry: an open-source toolbox for easy andrapid calculation of high-resolution glacier-velocity fields to The ...
Maximillian Van Wyk de Vries
core   +1 more source

Toward Sustainable Separation and Recovery of Critical Metals From Discarded Industrial Perovskite Solar Modules

Advanced Science, EarlyView.
An architecture‐guided recycling process enables selective metal recovery from end‐of‐life perovskite solar modules by exploiting interfacial accessibility and calcination‐induced phase transformation. The process achieves >99.8% Pb removal, >99.7% In recovery, and >96.1% Cu recovery, while selectively retaining Sn in leaching residue.
Guang Hu, Zhaoyang Li, Shifa Zhou, Jie Qin, Sha Liang, Huabo Duan, Liang Huang, Jingping Hu, Huijie Hou, Hongjie Zhou, Ling Xu, Chao Chen, Jiang Tang, Jiakuan Yang   +13 more
wiley   +1 more source