Results 61 to 70 of about 1,670 (266)

On non-dimensional forms of basal sliding laws and flow laws for ice-sheet and glacier modelling

Journal of Glaciology
Ice sheets and glaciers flow through basal sliding and internal deformation, each governed by physical laws commonly expressed as power-law relations. These formulations include coefficients—the sliding coefficient and rate factor—whose values and units ...
Ralf Greve
doaj   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Ecological interactions in glacier environments: a review of studies on a model Alpine glacier

Biological Reviews
ABSTRACTGlaciers host a variety of cold‐adapted taxa, many of which have not yet been described. Interactions among glacier organisms are even less clear. Understanding ecological interactions is crucial to unravelling the functioning of glacier ecosystems, particularly in light of current glacier retreat.
Crosta A., Valle B., Caccianiga M., Gobbi M., Ficetola F. G., Pittino F., Franzetti A., Azzoni R. S., Lencioni V., Senese A., Corlatti L., Buda J., Poniecka E., Novotna Jaromerska T., Zawierucha K., Ambrosini R.   +15 more
openaire   +6 more sources

Glacier thickness estimations of alpine glaciers using data and modeling constraints [PDF]

The Cryosphere, 2019
Abstract. Advanced knowledge of the ice thickness distribution within glaciers is of fundamental importance for several purposes, such as water resource management and the study of the impact of climate change. Ice thicknesses can be modeled using ice surface features, but the resulting models can be prone to considerable uncertainties.
L. Langhammer, M. Grab, M. Grab, A. Bauder, H. Maurer   +4 more
openaire   +4 more sources

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Single‐cell Transcriptome Profiling Reveals Gene Regulatory Networks and Key Genes in the Root Epidermis and Cortical Cells Associated with Early Nodulation in Glycine Max

Advanced Science, EarlyView.
Single‐cell transcriptomics of soybean roots soon after rhizobial inoculation reveals epidermal and cortical cell‐specific programs and gene‐regulatory networks acting in symbiosis establishment. We identify an ethylene‐driven regulatory circuit involving WRKY6.3/6.4 transcription factors targeting select Nod19 genes that promotes infection‐thread ...
Yongbin Zhuang, Yu Geng, Xinyu Guo, Chen Wang, Yongjing Sun, Luqi Liu, Li Liu, QianQian Gao, XinFang Zhu, Hongxiang Cao, Gengshuo Zhang, Yunxia Liu, Guobin Zhang, Baoyin Chen, Jinfei Zhang, Xin Hou, Xiaoming Li, Dajian Zhang   +17 more
wiley   +1 more source

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Discovery of the Fastest Ice Flow along the Central Flow Line of Austre Lovénbreen, a Poly-thermal Valley Glacier in Svalbard

Remote Sensing, 2019
Ice flow velocity is a sensitive indicator of glacier variations both controlling and representing the delivery of ice and affecting the future stability of ice masses in a warming climate.
Songtao Ai, Xi Ding, Jiachun An, Guobiao Lin, Zemin Wang, Ming Yan   +5 more
doaj   +1 more source

Modelling Dynamics of Valley Glaciers

, 2012
Ever since the Paleoproterozoic snowball Earth era, ca. 2.4 billion years ago (e.g. Hoffman & Schrag, 2000; Kirschvink, 1992), and beyond, the landscape of the planet Earth has been shaped up by the tremendous amount of scouring due to the repeated waxing and waning of ice masses.
Surendra Adhikari, Shawn J.
openaire   +2 more sources