Results 71 to 80 of about 1,670 (266)

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

Simulating seasonal evolution of subglacial hydrology at a surging glacier in the Karakoram

Journal of Glaciology
Glacier motion, retreat and glacier hazards such as surges and glacial lake outburst floods (GLOFs) are likely underpinned by subglacial hydrology. Recent advances in subglacial hydrological modeling allow us to shed light on subglacial processes that ...
Neosha G. Narayanan, Aleah N. Sommers, Winnie Chu, Jakob F. Steiner, Muhammad Adnan Siddique, Colin R. Meyer, Brent Minchew   +6 more
doaj   +1 more source

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

Improved representation of laminar and turbulent sheet flow in subglacial drainage models

Journal of Glaciology
Subglacial hydrology models struggle to reproduce seasonal drainage patterns that are consistent with observed subglacial water pressures and surface velocities. We modify the standard sheet-flow parameterization within a coupled sheet–channel subglacial
Tim Hill, Gwenn Elizabeth Flowers, Matthew James Hoffman, Derek Bingham, Mauro Angelo Werder   +4 more
doaj   +1 more source

Centreline and cross-glacier air temperature variability on an Alpine glacier: assessing temperature distribution methods and their influence on melt model calculations

Journal of Glaciology, 2017
The spatio-temporal distribution of air temperature over mountain glaciers can demonstrate complex patterns, yet it is often represented simplistically using linear vertical temperature gradients (VTGs) extrapolated from off-glacier locations. We analyse
THOMAS E. SHAW, BEN W. BROCK, ÁLVARO AYALA, NICK RUTTER, FRANCESCA PELLICCIOTTI   +4 more
doaj   +1 more source

Groundwater Rise Sustains the World's Largest Alpine Water System Under Global Warming

Advanced Science, EarlyView.
Shallow groundwater depth (SGWD) across the non‐permafrost plains of the Qinghai–Xizang Plateau decreased at averagely 0.02 m year−1, adding 31.44 Gt of freshwater storage from 2000 to 2020 and sustaining ∼53 500 km2 of alpine ecosystems. A vadose‐zone capacity of 426.6 Gt reveals these aquifers as promising reservoirs, highlighting groundwater's ...
Jianqing Du, Zhixiang Niu, Yanfen Wang, Shirui Zhou, Youqing Yang, Xiang Wei, Haishan Niu, Yitao Zhang, Anquan Xia, Yali Liu, Yanbin Hao, Kai Xue, Bingfang Wu, Xinquan Zhao, Tandong Yao, Yiyu Chen   +15 more
wiley   +1 more source

Future Retreat of Great Aletsch Glacier and Hintereisferner – application of a full-Stokes model to two valley glaciers in the European Alps [PDF]

The Cryosphere
We simulate the future evolution of two valley glaciers in the European Alps over the course of the 21st century. The model setup combines a numerical realization of full-Stokes ice dynamics coupled to a surface energy balance model forced with the ...
M. Rückamp, G. Cheng, G. Cheng, K. Gutjahr, M. Möller, P. K. E. Pellikka, P. K. E. Pellikka, C. Mayer   +7 more
doaj   +1 more source

High‐elevation endemic plants predicted to lose habitat from changing climate in Washington State

American Journal of Botany, EarlyView.
Abstract Premise High‐elevation plants face unique challenges from potential climate change impacts that will likely require upslope migration into increasingly smaller suitable habitat. This situation is particularly acute for endemic species that by definition occupy small geographic ranges.
Nicholas L. Gjording, Erik W. Ertsgaard, David E. Giblin, Iris H. Dimpsey, Owen B. Bard   +4 more
wiley   +1 more source

Simulating climatic mass balance, seasonal snow development and associated freshwater runoff in the Kongsfjord basin, Svalbard (1980–2016)

Journal of Glaciology, 2018
The Kongsfjord basin in northwest Svalbard is the site of a number of interdisciplinary studies concerned with the effect of fresh water from seasonal snow and glacier melt on the physical and biological environment.
ANKIT PRAMANIK, WARD VAN PELT, JACK KOHLER, THOMAS V. SCHULER   +3 more
doaj   +1 more source

Freedom dreaming of migrant justice: Critical reflections on counterspaces and institutional violence in the university

American Journal of Community Psychology, EarlyView.
Abstract US universities are built on stolen land and sustained through hierarchies of power that produce what migrant justice scholars name as b/order regimes. As institutions that claim to be sites of learning and inclusion, universities are fraught with contradictions as simultaneously sites of dispossession, exclusion, and control.
Sara L. Buckingham, Jesica Siham Fernández   +1 more
wiley   +1 more source