Results 131 to 140 of about 8,044,192 (299)

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

A New Ordered Transformation‐Induced Plasticity Enables Exceptional Strength and Ductility in a B2 Medium‐Entropy Alloy

Advanced Science, EarlyView.
A novel B2‐ordered Ti‐Zr‐V‐Al medium‐entropy intermetallic is developed through controlled metastability engineering, which activates an ordered TRIP effect via a new B2→D019‐α2 transformation with a distinctive {0001}α2//{110}B2, <11‐20>α2//<100>B2 orientation relationship. This alloy achieves an elongation of ∼7%, a strength of ∼1.1 GPa, and superior
Chaohua Li, Yidong Wu, Boyuan Zheng, Xu Zhang, Xiongjun Liu, Wenli Song, Ning An, Chengbo Xiao, Xidong Hui   +8 more
wiley   +1 more source

Glacier Retreat in Eastern Himalaya Drives Catastrophic Glacier Hazard Chain

Geophysical Research Letters
Cryospheric responses to climate warming include glacier retreat, altitude‐dependent thermal instability, and abundant meltwater, which increase the frequency of catastrophic glacier hazard chain (CGHC) events.
Yao Li, Yifei Cui, Xie Hu, Zhong Lu, Jian Guo, Yu Wang, Hao Wang, Shuofan Wang, Xinzhi Zhou   +8 more
doaj   +1 more source

Response of a marine-terminating Greenland outlet glacier to abrupt cooling 8200 and 9300 years ago [PDF]

, 2011
Long-term records of Greenland outlet-glacier change extending beyond the satellite era can inform future predictions of Greenland Ice Sheet behavior. Of particular relevance is elucidating the Greenland Ice Sheet's response to decadal- and centennial ...
Greg S. Babonis, Nicolás E. Young, Babonis, G.S., Robert C. Finkel, Rood, D.H., Csatho, B., Beata Csatho, Young, N.E., Axford, Y., Briner, J.P., Dylan H. Rood, Jason P. Briner, Yarrow Axford, Finkel, R.C.   +13 more
core   +1 more source

Magneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia

Advanced Science, EarlyView.
Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu   +6 more
wiley   +1 more source

Preliminary results of a low-frequency 3D-sar approach for glacier volume mapping

2010 IEEE International Geoscience and Remote Sensing Symposium, 2010
First experimental results with a low-frequency, ultra widebad (UWB) radar for estimating the height of glacier beds are illustrated. We use a 3-dimensional Time-Domain Back-Projection (TDBP) algorithm which incorporates the influence of the refractivity of ice to reconstruct the glacier bed of the Aletsch Glacier in the Swiss Alps using several ...
Henke, D, Meier, E
openaire   +2 more sources

High‐elevation endemic plants predicted to lose habitat from changing climate in Washington State

American Journal of Botany, EarlyView.
Abstract Premise High‐elevation plants face unique challenges from potential climate change impacts that will likely require upslope migration into increasingly smaller suitable habitat. This situation is particularly acute for endemic species that by definition occupy small geographic ranges.
Nicholas L. Gjording, Erik W. Ertsgaard, David E. Giblin, Iris H. Dimpsey, Owen B. Bard   +4 more
wiley   +1 more source

Ac‐SDKP modulates apoptosis via HSP27 and the FAS/FASL and mitochondrial axes

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of Ac‐SDKP regulating the FAS/FASL and mitochondrial apoptosis pathways via HSP27. Ac‐SDKP inhibits HSP27 expression, activates the FAS/FASL pathway and Caspase‐3 signaling, increases Caspase‐8 and Caspase‐3 expression, and induces cell apoptosis.
Wenxin Guo, Jinyin Yan, Wenli Li, Jin Wang, Lu Liu, Chengmei Zhang, Wei Cao, Shanshan Yao, Haibo Gong, Yi He, Zihan Zhou, Siyan Chen, Li Feng, Haijing Deng   +13 more
wiley   +1 more source

Glacier recession since the Little Ice Age: Implications for water storage in a Rocky Mountain landscape

Arctic, Antarctic, and Alpine Research, 2019
Glaciers have significant influence on hydrology, vegetation, and wildlife in mountainous regions, and are receding globally. To quantify the impacts of sustained glacier loss, we mapped a complete set of glacier areas from the Little Ice Age (LIA) using
Chelsea J. Martin-Mikle, Daniel B. Fagre
doaj   +1 more source

Calibrated Ice Thickness Estimate for All Glaciers in Austria

Frontiers in Earth Science, 2019
Knowledge on ice thickness distribution and total ice volume is a prerequisite for computing future glacier change for both glaciological and hydrological applications. Various ice thickness estimation methods have been developed but regional differences
Kay Helfricht, Matthias Huss, Matthias Huss, Andrea Fischer, Jan-Christoph Otto   +4 more
doaj   +1 more source