Results 111 to 120 of about 8,044,192 (299)

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Alpine glacier change in the Eastern Altun mountains of Northwest China during 1972-2010.

PLoS ONE, 2015
Accurately mapping and monitoring glacier changes over decades is important for providing information to support sustainable use of water resource in arid regions of northwest China.
Xinyang Yu, Changhe Lu
doaj   +1 more source

Increased rate of acceleration on Pine Island Glacier strongly coupled to changes in gravitational driving stress [PDF]

, 2009
Pine Island Glacier, Antarctica, has been undergoing several related changes for at least two decades; these include acceleration, thinning and grounding line retreat.
Scott, J. B. T., Vaughan, D G, Bingham, R. G., R. G. Bingham, Pritchard, H.D., Vaughan, D. G., Bingham, R.G., Pritchard, Hamish D., Scott, J.B.T., Smith, A. M., Vaughan, D.G., Pritchard, H. D., J. B. T. Scott, Gudmundsson, G H, Smith, A M, Pritchard, H D, Smith, A.M., Gudmundsson, G.H., D. G. Vaughan, Vaughan, David G., G. H. Gudmundsson, Scott, J B T, H. D. Pritchard, Bingham, R G, Gudmundsson, G. H., Gudmundsson, Hilmar, A. M. Smith, Bingham, Robert G.   +27 more
core   +2 more sources

Grain Boundary Structure Ordering via Electroshock Treatment Enhances Strength‐Ductility Synergy

Advanced Science, EarlyView.
Electroshock treatment triggers atomic rearrangement, transforming disordered grain boundaries into ordered states without inducing recrystallization. This grain boundary ordering effectively relieves strain concentration and strengthens boundaries, enabling a simultaneous improvement in both strength and ductility.
Jiancheng Chen, Feng Wang, Dongsheng Qian, Huiling Wang, Jinsong Wu, Mingwang Fu, Lin Hua   +6 more
wiley   +1 more source

Modeling Glacier Elevation Change from DEM Time Series

Remote Sensing, 2015
In this study, a methodology for glacier elevation reconstruction from Digital Elevation Model (DEM) time series (tDEM) is described for modeling the evolution of glacier elevation and estimating related volume change, with focus on medium-resolution and
Di Wang, Andreas Kääb
doaj   +1 more source

Recent volume loss of British Columbian glaciers, Canada

Geophysical Research Letters, 2007
We use the Shuttle Radar Topography Mission (SRTM) data and digital terrain models from aerial photography to quantify the change of glacier volume in British Columbia (BC), Canada for the period 1985–1999. We note substantial elevation bias in the SRTM elevations, typically on the order of −12 m km−1. The bias‐corrected thinning rate is −0.78 ± 0.19 m
E. Schiefer, B. Menounos, R. Wheate
openaire   +1 more source

Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation

Advanced Science, EarlyView.
Using a newly developed Droplet Interface Bilayer‐Pipette assay, the authors show that two segments of the CyaA toxin cross membranes by distinct mechanisms. One segment translocates spontaneously, whereas the translocation of the other depends on membrane potential.
Gaia Scilironi, Nicolas Carvalho, Jacinthe Frangieh, Corentin Léger, Dorothée Raoux‐Barbot, J. Iñaki Guijarro, Daniel Ladant, Sophie Cribier, Nicolas Rodriguez, Alexandre Chenal   +9 more
wiley   +1 more source

Mapping vanishing glaciers in Vorarlberg, Austria

Annals of Glaciology
We assess ongoing regional glacier loss in the Austrian state of Vorarlberg using a set of manually mapped glacier outlines for 2017, 2020, 2022 and 2023. Vorarlberg has lost about half of its glacierized area since a previous inventory in the mid-2000s.
Svenja Conzelmann, Bernd Seiser, Marcela Violeta Lauria, Giulia Bertolotti, Martin Stocker-Waldhuber, Andrea Fischer, Lea Hartl   +6 more
doaj   +1 more source

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source

Modelling PolSAR Scattering Signatures at Long Wavelengths of Glacier Ice Volumes [PDF]

, 2012
The crucial role of cryosphere for understanding the global climate change has been widely recognized in recent decades [1]. Glaciers and ice sheets are the main components of the cryosphere and constitute the basic reservoir of fresh water for high ...
Jagdhuber, Thomas, Hajnsek, Irena, Parrella, Giuseppe, Al-Kahachi, Noora, Papathanassiou, Kostantinos   +4 more
core