Results 71 to 80 of about 13,825 (267)
Advanced Science, EarlyView.Microgels enable independent control of stiffness and interstitial space, overcoming limitations of conventional 3D hydrogels. Using fragmented gelatin methacryloyl microgels, we show that stiffness does not restrict non‐metastatic breast cancer growth, contrary to bulk hydrogels, and reveal the role of adherent‐to‐suspension transition in cancer ...
Danielle Vahala +15 more
wiley +1 more source
Advanced Science, EarlyView.Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li +7 more
wiley +1 more source
Glacier Flow and the Growth of the Glacier Grain [PDF]
Journal of Glaciology, 1947 The crystallographic results of the Jungfraujoch Research Party’s investigations were published in the Proceedings of the Royal Society in August 1939. It has since occurred to me that insufficient attention was drawn to another factor affecting the movement and growth of the glacier grain ...
openaire +1 more source
Advanced Science, EarlyView.Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne +15 more
wiley +1 more source
Narrowing of glacial isthmus between Sørkapp Land and Torell Land, southern Spitsbergen, 1900–2023
Journal of MapsThe paper provides a comprehensive overview of the transformation of the glacial isthmus between Sørkapp Land (southern peninsula) and the remainder of Spitsbergen from 1900 to 2023.
Michał Pawłowski, Krzysztof Ostafin
doaj +1 more source
TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma
Advanced Science, EarlyView.TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin +9 more
wiley +1 more source
Advanced Science, EarlyView.A novel B2‐ordered Ti‐Zr‐V‐Al medium‐entropy intermetallic is developed through controlled metastability engineering, which activates an ordered TRIP effect via a new B2→D019‐α2 transformation with a distinctive {0001}α2//{110}B2, <11‐20>α2//<100>B2 orientation relationship. This alloy achieves an elongation of ∼7%, a strength of ∼1.1 GPa, and superior
Chaohua Li +8 more
wiley +1 more source
Self-affine structure of glacial surfaces in Lombardy
Environmental Research CommunicationsThe surface of a glacier represents the interface with the atmosphere where mass and energy fluxes exchanges occur due to the exposition to solar radiation, precipitation (solid and liquid) and wind currents.
Marina Carpineti +7 more
doaj +1 more source