Results 61 to 70 of about 8,113 (274)

Efficacy of finafloxacin in a murine model of inhalational glanders

Frontiers in Microbiology, 2022
Burkholderia mallei, the causative agent of glanders, is principally a disease of equines, although it can also infect humans and is categorized by the U.S. Centers for Disease Control and Prevention as a category B biological agent.
Kay B. Barnes, Marc Bayliss, Carwyn Davies, Mark I. Richards, Thomas R. Laws, Andreas Vente, Sarah V. Harding, Sarah V. Harding   +7 more
doaj   +1 more source

2D Bipyrimidine silver(I) nitrate: Synthesis, X-ray structure, solution chemistry and anti-microbial activit [PDF]

, 2011
Synthesis and X-ray single crystal structure analysis of the compound {[Ag2(μ2-bpym)(μ-O-NO3)2]}n, (1), (where bpym = 2,2′-bipyrimidine) are presented. Compound (1) has a (6,3)-2D honeycomb structure with a tetrahedral coordination geometry around the Ag(
Abu-Youssef, Morsy A.M., Gohar, Yousry M., Jänis, Janne, Langer, Vratislav, Massoud, Alshima'a A., Öhrström, Lars   +5 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Scientific Opinion on animal health risk mitigation treatments as regards imports of animal casings [PDF]

, 2012
<p>Salting with NaCl for 30 days is a well-established and accepted procedure in the casings industry and it has been the standard animal health risk mitigation treatment prescribed in EU legislation for many years.
EFSA Panel on Animal Health and Welfare
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Detection of unsoundness and vice in horses [PDF]

, 1902
Citation: Ross, John F. Detection of unsoundness and vice in horses. Senior thesis, Kansas State Agricultural College, 1902.Morse Department of Special CollectionsIntroduction: What is soundness?
Ross, John F.
core  

Rapid identification of Burkholderia mallei and Burkholderia pseudomallei by intact cell Matrix-assisted Laser Desorption/Ionisation mass spectrometric typing [PDF]

, 2012
BACKGROUND: Burkholderia (B.) pseudomallei and B. mallei are genetically closely related species. B. pseudomallei causes melioidosis in humans and animals, whereas B. mallei is the causative agent of glanders in equines and rarely also in humans.
Axel Karger, Barbara Bettin, Falk Melzer, Heinrich Neubauer, Herbert Tomaso, Holger C Scholz, Mandy C Elschner, Mario Ziller, Markus Kostrzewa, Rüdiger Stock, Thomas Maier   +10 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source

Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species [PDF]

, 2017
Burkholderia is a genus within the β-Proteobacteriaceae that contains at least 90 validly named species which can be found in a diverse range of environments. A number of pathogenic species occur within the genus.
Butt, A.T., Thomas, M.S.
core   +7 more sources