Results 41 to 50 of about 400,221 (265)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A novel method of complex evaluation of meibomian glands morphological and functional state

Oftalʹmologiâ, 2014
A novel method that provides complex assessment of meibomian glands morphological and functional state — biometry of meibomian glands — was developed. The results of complex examination (including meibomian glands biometry), correlation analysis data and
V. N. Trubilin, E. G. Polunina, A. E. Alieva, V. V. Kurenkov, A. V. Zhemchugova   +4 more
doaj   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Morphological aspects of the salivary glands of Crab-eating racoon (Procyon cancrivorus) - doi: 10.4025/actascibiolsci.v35i1.12675

Acta Scientiarum: Biological Sciences, 2012
Procyon cancrivorus is a wild mammal from the Procyonidae family, being one of the least studied Brazilian carnivores. The aim of this study was to describe the morphological aspects of the salivary glands of Procyon cancrivorus, and to compare with ...
Kleber Fernando Pereira, Daiane Rodrigues Souza, Lorraine Silva Ferreira, Pâmella Rosa Chela, Carla Helrigle, Eugênio Gonçalves de Araújo   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Environmentally independent histological markers of wool quality: a comparative study of Gentile di Puglia and Sarda breeds

Frontiers in Animal Science
Wool quality plays a role in determining the economic value of sheep breeds, amid the growing global demand for natural and sustainable material. This quality depends on both genetic and non-genetic factors, complicating breed evaluation.
Rossana Topputi, Maria Gabriela Molina, Gianluca Ventriglia, Jorge Quiroz Valiente, Miguel Angel Ramirez Guillermo, Silvia Bruno, Elena Ciani, Lorenzo Guerra, Alberto Cesarani, Alberto Cesarani, Alberto Cesarani, Vincenzo Landi, Tiziana Martinello   +12 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Isoproterenol (beta-adrenergic agonist) induces chloride ion secretion from the glands of frog skin

National Journal of Physiology, Pharmacy and Pharmacology
Background: The study focused on the glandular epithelium, an essential part of the frog's skin that contains receptors for various chemicals. These glands include mucosal, serosal–mucous, and poisonous types.
Silviya Rajakumari Jared
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source