Results 61 to 70 of about 400,221 (265)
Postgraduate Medical Journal, 1936 The pituitary gland has come to be regarded as the master key of the endocrine system in so far as it influences the activity of the remaining glands, but a reciprocal influence in the opposite direction is equally important. Hypophysectomy results in diminished function and some degree of.
openaire +2 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
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A Case Report: A Giant Adrenal Myelolipoma [PDF]
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2009 Background and ObjectivesAdrenal myelolipoma is a rare benign condition. Most of these tumors are diagnosed as incidental findings during imaging. The asymptomatic patient with small lesion should be followed, but the symptomatic patient with functional ...
P. Shapoori
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Sociobiology, 2014 Social insects are known for their overwhelming diversity of exocrine glands. This study examines the glands in the legs of workers of Frieseomelitta varia (Lepeletier).
Johan Billen, Lore Vander Plancken
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Caspase-3 mediated Apoptosis AT the endometrial hyperplasia in women of reproductive age
Journal of Education, Health and Sport, 2016 Dubinina V. G., Nosenko O. M., Vizir K. P., Kaushik O. A. Caspase-3 mediated Apoptosis AT the endometrial hyperplasia in women of reproductive age. Journal of Education, Health and Sport. 2016;6(12):883-894. eISSN 2391-8306.
V. G. Dubinina +3 more
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