Results 111 to 120 of about 110,373 (308)

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Abundance and distribution of California sea lions (Zalophus californianus) in central and northern California during 1998 and summer 1999 [PDF]

, 2005
The abundance and distribution of California sea lions (Zalophus californianus) in central and northern California was studied to allow future evaluation of their impact on salmonids, the ecosystem, and f isheries.
Forney, Karin A., Lowry, Mark S.
core  

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

PCR-based characterisation of entomopathogenic fungi for ecological studies [PDF]

, 2008
The implementation of PCR-based tools for characterisation of organisms has greatly advanced our understanding of the phylogenies and species boundaries in entomopathogenic fungi, especially the widespread taxa Beauveria bassiana and Metarhizium ...
Meyling, Nicolai V.
core  

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

An Enhanced NSGA-II Algorithm with Parameter Categorization for Computational-Efficient Multi-Objective Optimization of Active Glass Curtain Wall Shading Systems

Energies
To address the limitations of the Non-Dominated Sorting Genetic Algorithm (NSGA-II) in optimizing active glass curtain wall shading systems—particularly its suboptimal convergence efficiency and high computational demands—this study proposes an improved ...
Dezhao Tang, Zhiyong Wang
doaj   +1 more source

KDM4A Erases the H3R17me2a Mark, Facilitating Chromosome Condensation

Advanced Science, EarlyView.
This study reveals a reversible histone modification switch governing chromosome condensation during mitosis. PKCα‐activated KDM4A removes H3R17me2a, permitting Suv39h1‐driven H3K9me3 deposition. This epigenetic transition recruits the chromosomal passenger complex and triggers Aurora B‐dependent H3S10 phosphorylation, coordinating chromatin remodeling
Yena Cho, Jee Won Hwang, Gyu Hwan Hyun, Sangkyu Lee, Dae‐Geun Song, Su‐Nam Kim, Yong Kee Kim   +6 more
wiley   +1 more source

Local Reinforcement in Notched Fiber Metal Laminates by Bonding Titanium Patch

MATEC Web of Conferences, 2017
In order to reduce the stress concentration in notched fiber metal laminate (FML) and improve its damage tolerance, the local reinforcement concept was employed in present paper. Two different reinforced structures were proposed by bonding titanium patch
Zhang Jipeng, Wang Yue, Zhang Jiazhen, Zhou Zhengong   +3 more
doaj   +1 more source

Constraints on Physical Properties of z~6 Galaxies Using Cosmological Hydrodynamic Simulations

, 2007
We conduct a detailed comparison of broad-band spectral energy distributions of six z >= 5.5 galaxies against galaxies drawn from cosmological hydrodynamic simulations.
Ajiki, Balogh, Benjamin D. Oppenheimer, Benítez, Berger, Bouwens, Bouwens, Bouwens, Bruzual, Bunker, Calzetti, Cardelli, Charlot, Chary, Cuby, Davé, Davé, Dawson, Dickinson, Drory, Dunlop, Egami, Erb, Eyles, Eyles, Fan, Fardal, Finlator, Gawiser, González-Serrano, Gordon, Gwyn, Haardt, Hu, Hu, Iben, Idzi, Kashikawa, Kauffmann, Kawai, Kennicutt, Keres, Kneib, Kodaira, Kolatt, Kristian Finlator, Kurk, Labbé, Madau, Malhotra, Malhotra, Maraston, Martin, McKee, Mobasher, Murray, Nagao, Nagao, Night, Oppenheimer, Ouchi, Papovich, Papovich, Rhoads, Rhoads, Rhoads, Romeel Davé, Rupke, Santos, Schaerer, Shapley, Shapley, Shimasaku, Smail, Somerville, Spergel, Spergel, Springel, Springel, Springel, Springel, Stanway, Stanway, Stanway, Stern, Stiavelli, Wang, Wang, Westra, Yan   +89 more
core   +3 more sources