Results 41 to 50 of about 1,129,384 (247)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Enhanced luminescence at 2.88 and 2.04 μm from Ho3+/Yb3+ codoped low phonon energy TeO2–TiO2–La2O3 glass

open access: yesAIP Advances, 2019
The high phonon energy and short infrared cut-off wavelength of conventional oxide glass (or crystal) hosts are the limitations to achieve mid-infrared (MIR, λ≥2.5μm) luminescence.
Gaurav Gupta   +3 more
doaj   +1 more source

Differentiation in Architecture by Professional Designs and New Materials

open access: yesChallenging Glass Conference Proceedings, 2018
The economy globalizes. The industries concentrate. The productions become uniform. Cultural specificities disappear. About architecture and glass in architecture, it is the same phenomenon. Is this movement good or not?
Emmanuel Barrois   +2 more
doaj   +1 more source

A comparison study to develop the strategy for designing traditional Glass products in Egypt

open access: yesJournal of Architecture, Art & Humanistic Science, 2021
Traditional glass industry in Egypt is one of the most important traditional handicraft industries, it distinguished by high artistic and aesthetic value in production.
Sara Ahmed Zaki   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Crystallization and thermo-mechanical properties of Li2O-ZnO-CaOSiO2 glass-ceramics with In2O3 and Fe2O3 additives [PDF]

open access: yesProcessing and Application of Ceramics, 2015
Li2O-ZnO-CaO-SiO2 based glasses were prepared by the conventional melting technique and subsequently converted to glass-ceramics by controlled crystallization.
Saad M. Salman   +2 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Arsenic-free Ge-Te-based ovonic threshold switching material with reduced leakage current

open access: yesScientific Reports
There is growing interest in next-generation semiconductor memory that combines high speed, large capacity, and non-volatility. Many types of emerging memory technologies, such as PCRAM and MRAM, are being developed utilizing 3D crossbar array structures
Yoshimasa Matsushita   +7 more
doaj   +1 more source

Effect of B2O3 on structure, properties and tube forming of medium borosilicate pharmaceutical glasses

open access: yesJournal of Asian Ceramic Societies
At recent, medium borosilicate glass is most commonly used as the main material of medical glass at home and abroad. In this paper the influence of B2O3 on the structure and properties of medium borosilicate medical glass was studied in this paper.
Changqing Li   +7 more
doaj   +1 more source

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