Results 61 to 70 of about 1,695,620 (314)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Mechanical relaxation in glasses and at the glass transition [PDF]

Physical Review B, 2001
The Gilroy-Phillips model of relaxational jumps in asymmetric double-well potentials, developed for the Arrhenius-type secondary relaxations of the glass phase, is extended to a formal description of the breakdown of the shear modulus at the glass transition, the flow process.
openaire   +3 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Glass breaks : from nickel sulfide inclusions [PDF]

, 2006
Interest in nickel sulfide inclusions in glass dates to the 1960s. In recent years theoretical studies onthe phase changes in nickel sulfide from a combination of thermal analyses, x-ray powder diffraction and Raman spectroscopy using reagent-grade ...
Ray, AS, Jacob, L
core  

Arsenic-free Ge-Te-based ovonic threshold switching material with reduced leakage current

Scientific Reports
There is growing interest in next-generation semiconductor memory that combines high speed, large capacity, and non-volatility. Many types of emerging memory technologies, such as PCRAM and MRAM, are being developed utilizing 3D crossbar array structures
Yoshimasa Matsushita, Yi Shuang, Kosuke Karakida, Eisuke Takao, Naoki Toyofuku, Fumio Sato, Ken Choju, Yuji Sutou   +7 more
doaj   +1 more source

Redispersible polymer powder modified cementitious tile adhesive as an alternative to ordinary cement-sand grout

Heliyon, 2021
With the advent of technologies on modern structural and building materials, adaptation of such technological features has been the pivotal concern of researchers.
Mashrafi Bin Mobarak, Md. Sahadat Hossain, Monika Mahmud, Samina Ahmed   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Regeneration Of Thermally Recycled Glass Fibre For Cost-Effective Composite Recycling : Overview of the ReCoVeR projects [PDF]

, 2014
Global production of composite materials in 2015 will significantly exceed 10 million tons. Glass fibre reinforced composites account for more than 90% of all the fibre-reinforced composites currently produced.
Thomason, James, Saez Rodriguez, Eduardo, Nagel, Ulf, Kao, Chih-Chuan, Yang, Liu, Jenkins, Peter   +5 more
core  

Crystallization and thermo-mechanical properties of Li2O-ZnO-CaOSiO2 glass-ceramics with In2O3 and Fe2O3 additives [PDF]

Processing and Application of Ceramics, 2015
Li2O-ZnO-CaO-SiO2 based glasses were prepared by the conventional melting technique and subsequently converted to glass-ceramics by controlled crystallization.
Saad M. Salman, Samia N. Salama, Ebrahim A. Mahdy   +2 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source