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Thermodynamics and Crystallization Behavior of Meropenem Influenced by Solvent Composition and pH [PDF]

open access: yesMolecules
To develop an improved crystallization process for meropenem trihydrate, an important carbapenem antibiotic, the pH-dependent solubility of meropenem trihydrate in different solvent systems was investigated using the laser monitoring dynamic method.
Jinshen Ren   +7 more
doaj   +2 more sources

Thermodynamic Properties of 1,5-Pentanediamine Adipate Dihydrate in Three Binary Solvent Systems from 278.15 K to 313.15 K

open access: yesCrystals, 2022
In this work, solubility data of 1,5-pentanediamine adipate dihydrate in binary solvent systems of water + methanol, water + ethanol and water + N,N-dimethylformamide were experimentally measured via a static gravimetric method in the temperature range ...
Liang Li   +8 more
doaj   +1 more source

Enhancement of Crystallization Process of the Organic Pharmaceutical Molecules through High Pressure

open access: yesCrystals, 2022
The enhancement of the crystallization process through high pressures was studied by using ribavirin (RVB) as a model compound. The effects of high pressure on crystallization thermodynamics, nucleation kinetics, and process yield were evaluated and ...
Yaoguang Feng   +5 more
doaj   +1 more source

Spatiotemporal control of l-phenylalanine crystallization in microemulsion: the role of water in mediating molecular self-assembly

open access: yesIUCrJ, 2022
Water confined or constrained in a cellular environment can exhibit a diverse structural and dynamical role and hence will affect the self-assembly behavior of biomolecules.
Qi Liu   +6 more
doaj   +1 more source

Novel materials and crystallizer design for freeze concentration

open access: yesScientific African, 2023
When wastewater streams or seawater are desalinated, the waste product is a hypersaline brine stream which is usually disposed of or stored in evaporation ponds.
Alison Emslie Lewis   +5 more
doaj   +1 more source

The Effect of Solvents on the Crystal Morphology of Pyriproxyfen

open access: yesCrystals, 2023
To obtain crystal products with ideal morphology and better quality, it is important to fully understand and grasp the affecting mechanism of solvents on crystal morphology.
Xiaoyang Yan   +7 more
doaj   +1 more source

Impact of Impurities on Crystallization and Product Quality: A Case Study with Paracetamol

open access: yesCrystals, 2021
A thorough, systematic study into the effect that structurally related impurities have on both the process and product quality during the crystallization of an active pharmaceutical ingredient is presented.
Stephanie J. Urwin   +3 more
doaj   +1 more source

Partial Oxidation Strategy to Synthesize WS2/WO3 Heterostructure with Enhanced Adsorption Performance for Organic Dyes: Synthesis, Modelling, and Mechanism

open access: yesNanomaterials, 2020
In this work, a facile oxidation strategy was developed to prepare novel tungsten disulfide/tungsten trioxide (WS2/WO3) heterostructures for adsorbing organic dyes efficiently by combining the hydrophilic property of WO3 and the superior dye affinity of ...
Guiping Li   +6 more
doaj   +1 more source

Gypsum Seeding to Prevent Scaling

open access: yesCrystals, 2022
Eutectic freeze crystallization (EFC) is a novel separation technique that can be applied to treat brine solutions such as reverse osmosis retentates. These are often a mixture of different inorganic solutes. The treatment of calcium sulphate-rich brines
Taona Malvin Chagwedera   +2 more
doaj   +1 more source

Targeting Desired Particle Size for Improved Dissolution and Manufacturability of Mefenamic Acid

open access: yesChemistry Proceedings, 2022
This work aims at the production of uniformly sized, equant shaped crystals using a direct nucleation control (DNC) strategy to help achieve enhanced manufacturability and bioavailability of the active pharmaceutical ingredients (API).
Wei Li, Chris D. Rielly, Brahim Benyahia
doaj   +1 more source

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