Results 71 to 80 of about 3,924,160 (300)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Spin-Glass and Chiral-Glass Transitions in a $\pm J$ Heisenberg Spin-Glass Model in Three Dimensions

, 2001
The three-dimensional $\pm J$ Heisenberg spin-glass model is investigated by the non-equilibrium relaxation method from the paramagnetic state. Finite-size effects in the non-equilibrium relaxation are analyzed, and the relaxation functions of the spin ...
Binder K., Blundell R. E., Bray A. J., de Courtenary N., Endoh S., Gunnarsson K., Hukushima K., Huse D. A., Janssen H. K., Kawamura H., Kawamura H., Kawamura H., Kawashima N., Matsubara F., Matsubara F., Matsubara F., McMillan W. L., Mydosh J. A., Olive J. A., Ozeki Y., Sadic A., Shirahata T., Stauffer D., Vincent E.   +23 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Adhesion of Laminated Glass Interlayer in a Double Cantilever Beam Test

Challenging Glass Conference Proceedings
Laminated glass is a key safety element in modern building with glass façades. Tuning the adhesion between the interlayer and the glass as well as the mechanical properties of the interlayer are essentials to both the quality of the laminated glass ...
Paul Elziere, Yael Bronstein, Fabien Levasseur, Francis Serruys   +3 more
doaj   +1 more source

Influence of Temperature on Laminated Glass Performances Assembled with Various Interlayers

Challenging Glass Conference Proceedings, 2016
The increasing demand for use of laminated glass in building facades is the driving force for new interlayers testing and their implementation.
M. Novotny, B. Poot
doaj   +1 more source

Glasses for Glass Electrode

The Journal of the Society of Chemical Industry, Japan, 1958
今日,pHの測定には,ほとんどガラス電極が使用されている現状であり,また,このガラス電極の進歩によって,更に,pH自動制御の可能性が生まれてきた。本研究ではガラス電極用ガラスの性能改良化を目的として,リチウム・ガラス(Li2O含量を26～28mol%に固定)の組成を系統的に変化させ,各ガラス成分のガラス電極特性に及ぼす影響を検討してみた。その結果,ZrO2,CeO2,Al2O3,V2O5,B2O3等の成分で,BaOを置換していくと,いずれもアルカリ誤差の大きくなることがわかった。また,アルカリ誤差の小さいガラスの組成は,SiO259～64mo1%,Li2O26～28mol%,La2O3+ BaO10～13mo1%であった。
Shinzo Okada, Tomota Nishi, Hiroshi Takahashi   +2 more
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source