Results 51 to 60 of about 25,918 (188)

AZP2006 in Progressive Supranuclear Palsy: Outcomes from a Phase 2a Multicenter, Randomized Trial, and Open‐Label Extension on Safety, Biomarkers, and Disease Progression

Movement Disorders, Volume 40, Issue 12, Page 2700-2709, December 2025.
Abstract Objectives The aim was to evaluate the safety, tolerability, pharmacokinetics, and potential clinical efficacy of AZP2006, an oral pleiotropic drug modulating progranulin levels, in patients with progressive supranuclear palsy (PSP), a rare tauopathy. Methods A randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted at
Jean‐Christophe Corvol, Mickael Alexandre Obadia, Caroline Moreau, Louise‐Laure Mariani, Jean‐Philippe Brandel, David Devos, Sara Sambin, Nicolas Carrière, Günter Höglinger, Marie Lebouteux, Graziella Mangone, Noelle Callizot, Aurélien Blondel, Olivier Defert, Cecilia Estrella, Artin Karapet, Philippe Verwaerde, Luc Defebvre   +17 more
wiley   +1 more source

as carreras académicas de mujeres y hombres en la Universidad de Alicante

Sociología del Trabajo, 2014
El artículo presenta las conclusiones de la investigación «Evaluación de la concilia-ción, corresponsabilidad y promoción profesional en la Universidad de Alicante».
María José Rodríguez Jaume, María José González Río, Mari Carmen Albert Guardiola   +2 more
doaj   +2 more sources

Study of conditions to evaluate light hypersensitivity in a light–dark box using a mouse model and a mydriatic

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.
Abstract Aim The pathophysiology and treatment of sensory hypersensitivity remain unclear. This study aimed to identify a simple behavioral analysis device and animal model evaluating glare sensitivity and to test the effects of psychotropic drugs using this device.
Shogo Hirota, Leo Gotoh, Reo Hayashi, Yoshikazu Kitai, Hideki Matsuoka, Masato Masuda, Hiroaki Kawasaki, Hikaru Hori   +7 more
wiley   +1 more source

Applying Basic Ergonomic Principles Improves the Quality of Teaching-learning Environment in the Junior Secondary School [PDF]

, 2011
This study was conducted at the relatively young public junior secondary school at the district of Abiansemal and Administrative Region of Badung (SMPN-3) now aspiring to obtain national accreditation. In this context, the need was felt for improving the
Adiputra, N. (N), Ardana, I. G. (I), Manuaba, A. (A), Sutajaya, M. (M)   +3 more
core  

MEASURING OF GLASS CEILING SYNDROME AS A RESULT OF GENDER-BASED CONTRADICTORY BEHAVIOURS DEVELOPED AGAINST FEMALE EMPLOYEES IN THE ORGANIZATIONAL AMBIENT

INTERNATIONAL REFEREED JOURNAL OF HUMANITIES AND ACADEMIC SCIENCES, 2014
Hakan Kara, Bülent TOKAT, Alev DOĞRU
openalex   +2 more sources

In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses

The FEBS Journal, Volume 292, Issue 23, Page 6365-6399, December 2025.
GLE1 plays a direct role mRNA regulation, translation, and formation of cytosolic stress granules. GLE1 dysfunction has been associated with devastating diseases, including lethal congenital contracture syndrome 1(LCCS1), a rare disorder enriched in isolated populations.
Tomáš Zárybnický, Sonja Lindfors, Saana Metso, Julia Koivula, Zoltan Szabo, Rasmus Valtonen, Mikko Tulppo, Johanna Magga, Samu Saarimäki, Sonja Bläuer, Ilkka Miinalainen, Risto Kerkelä, Petteri. T. Piepponen, Vootele Voikar, Juho Väänänen, Riikka Kivelä, Bhagwan Yadav, Hanna Lindgren, Pirkko Mattila, Fu‐Ping Zhang, Petra Sipilä, Reetta Hinttala, Satu Kuure   +22 more
wiley   +1 more source

Massive reduction of RyR1 in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis

The Journal of Physiology, Volume 603, Issue 22, Page 6949-6977, November 15, 2025.
Abstract figure legend Intrafusal muscles contained within muscle spindles are endowed with ryanodie receptor 1 (RyR1) calcium channels and participate in proprioceptor function. Mutations in RyR1 linked to severe RYR1‐congenital myopathies affect calcium release from both extrafusal as well as intrafusal muscles.
Alexis Ruiz, Sofia Benucci, Hervé Meier, Georg Schultz, Katarzyna Buczak, Christoph Handschin, Rodrigo C. G. Pena, Susan Treves, Francesco Zorzato   +8 more
wiley   +1 more source

Dreamy Dwellings: How the Sleep Environment Affects Sleep Health in Adults—A Narrative Review

Lifestyle Medicine, Volume 6, Issue 4, October 2025.
ABSTRACT Sufficient high‐quality, well‐timed sleep is essential to health and physical, cognitive and emotional functions. Historically, environmental factors such as threats from other beings have likely constrained sleep. Newer sources of sleep disruption include modern work schedules, climate change, light pollution and noise pollution.
Gregory David Maxwell Potter, Gregory J. Grosicki, Grant M. Tinsley, Thomas R. Wood, Dan Garner, Andrew J. Galpin   +5 more
wiley   +1 more source

Normative and systems integration in human resource management in Japanese multinational companies [PDF]

, 2016
Purpose This paper aims to conceptualise a framework of “transnational human resource management” (HRM) and to demonstrate the validity of the model.
Brewster, Chris, Furusawa, Masayuki, Takashina, Toshinori   +2 more
core   +1 more source

François Hollande is by no means certain to win the French Presidential election. He may yet fall foul of France’s well-known ‘Frontrunner Syndrome’, as Sarkozy’s fightback begins. [PDF]

, 2012
In the run up to France’s presidential election on 22 April opinion polls place President Nicolas Sarkozy on the back foot against the Socialist candidate François Hollande. Yet Rainbow Murray argues that the contest is far from over yet.
Murray, Rainbow
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