Results 121 to 130 of about 3,547 (232)

Regio‐ and Diastereoselective C–C Silylation of Cyclopropyl Acetates Harnessing Fluorinated Poly(pyridyl)Borate Rhodium Catalysts

open access: yesChemistry – A European Journal, Volume 32, Issue 14, 15 April 2026.
Fluorinated poly(pyridyl)borates have been utilized to stabilize rhodium‐diene complexes and as supporting ligands in rhodium‐catalyzed redox‐neutral C–C silylation of cyclopropyl acetates, producing silicon‐containing heterocyclic products, dioxasilolanes.
Vo Quang Huy Phan   +3 more
wiley   +1 more source

Synthesis of Polyhydroxylated Pyrrolidinyl Analogs of Sugar Nucleotides. Experimental and Computational Studies on Their Interactions With GalNAC‐T's

open access: yesChemBioChem, Volume 27, Issue 7, 14 April 2026.
A multidisciplinary approach based on organic synthesis supported by quantum mechanical calculations, efficient phosphorylation methods, affinity studies using conventional techniques and saturation transfer difference nuclear magnetic resonance, together with molecular dynamics simulations, has enabled the preparation of nucleotide analogs with ...
Pedro Merino   +10 more
wiley   +1 more source

Effect of Co-exposure to Heat and Psychological Stressors on Sperm DNA and Semen Parameters. [PDF]

open access: yesToxicol Rep, 2021
Abdollahi F   +5 more
europepmc   +1 more source

Development of Styryl‐Modified 3,4‐Dihydropyrimidin‐2(1H)‐ones as Potential Antitumor Agents

open access: yesChemMedChem, Volume 21, Issue 7, 14 April 2026.
Styryl‐modified 3,4‐dihydropyrimidin‐2(1H)‐ones (DHPMs), designed from the Eg5 inhibitor monastrol, show markedly enhanced antiproliferative activity in HeLa and MCF‐7 cancer cells. Lead compounds 16 and 17 trigger apoptosis through cell‐line‐specific pathways and downregulate c‐Myc, emerging as promising anticancer candidates.
Konstantinos Panagoulias   +10 more
wiley   +1 more source

Modulating IDO1 and TDO Inhibition Through Structural Modification of Diaryl Hydroxylamines

open access: yesChemMedChem, Volume 21, Issue 7, 14 April 2026.
Diaryl hydroxylamines have emerged as promising scaffolds for targeting the tryptophan‐catabolizing enzymes indoleamine 2,3‐dioxygenase 1 (IDO1) and tryptophan 2,3‐dioxygenase (TDO), key drivers of tumor immune escape. Building on the reported dual IDO1/TDO inhibitory activity of O‐((3,5‐difluorophenyl)(phenyl)methyl)hydroxylamine, a series of diaryl ...
Angeliki S. Foscolos   +8 more
wiley   +1 more source

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