Results 141 to 150 of about 21,105,669 (168)

Glaucocalyxin A attenuates angiotensin II-induced cardiac fibrosis in cardiac fibroblasts

Biochemical and Biophysical Research Communications, 2018
Glaucocalyxin A (GLA) is a natural ent-Kaurane diterpenoid that possesses cardioprotective effect. Recently, it has been reported that GLA inhibits liver and pulmonary fibrosis, whereas its role in cardiac fibrosis remains unknown. In the present study, we evaluated the effect of GLA on the pathogenesis of cardiac fibrosis in vitro.
Qianqian, Su, Yuan, Zhang
openaire   +2 more sources

Network pharmacology analysis and biological validation of molecular targets regulated by glaucocalyxin a in periodontitis.

Biochemical and Biophysical Research Communications
Y. Xin, Zichen Xu, JiaYing Guan, Junjie Zheng, Chenhan Hua, Q. Jiang, Quan Li, Jianlin Fan   +7 more
semanticscholar   +2 more sources

Synthesis and biological evaluation of glaucocalyxin A derivatives as potential anticancer agents

European Journal of Medicinal Chemistry, 2014
A series of Mannich base type derivatives of Glaucocalyxin A (GLA) were designed and prepared. The cytotoxicity of these compounds was evaluated against six tumor cell lines (SMMC-7721, B16, SGC-7901, A549, KB, HL-60). Most compounds exhibited potent antiproliferative effects with low micromolar IC50 values.
Jing, Yang, Yanli, Liu, Chengwen, Xue, Wei, Yu, Jian, Zhang, Chunhua, Qiao   +5 more
openaire   +2 more sources

Glaucocalyxin A Induces Cytotoxicity in Renal Cancer Cells via ROS‐Mediated Autophagy by Direct Targeting of Antioxidant Enzymes PRDX1 and PRDX2

Advances in Biology
Glaucocalyxin A (GLA), a bioactive diterpenoid from the medicinal plant Rabdosia japonica, demonstrates potent antitumor activity, yet its molecular mechanisms in renal cell carcinoma (RCC) remain elusive. Here, GLA is reported to trigger cytotoxicity in
Yaping Niu, Jinhuan Ou, Xiaoru Zhong, Piao Luo, Junhui Chen, A. Iyaswamy, Haibo Tong, Zhou Zhu, Pengchen Chen, Xu Wei, Wei Zhang, Hualin Ma, Yulin Feng, Chuanbin Yang, Jigang Wang   +14 more
semanticscholar   +1 more source

Simultaneous determination of glaucocalyxin A and glaucocalyxin B in rat plasma by LC‐MS/MS and its application to a pharmacokinetic study after oral administration of Rabdosia japonica extract

Biomedical Chromatography, 2017
AbstractA specific and sensitive liquid chromatography tandem mass spectrometry (LC‐MS/MS) method was developed and validated for the analysis of glaucocalyxin A and glaucocalyxin B in rat plasma using praeruptorin A as an internal standard. Separation was performed on a Hypurity C18 column (2.1 × 50 mm, 5 μm) with isocratic elution using 0.2% formic ...
Weili Huang, Xiaohui Guan, Yongchen Lv
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Glaucocalyxin A induces apoptosis in human leukemia HL-60 cells through mitochondria-mediated death pathway

Toxicology in Vitro, 2011
Glaucocalyxin A (GLA) is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx, a traditional Chinese medicinal herb, which has been shown to inhibit tumor cell proliferation. However, the mechanism underlying GLA-induced cytotoxicity remains unclear. In this study, we focused on the effect of GLA induction on
Li Wen, Gao, Jian, Zhang, Wen Hua, Yang, Bin, Wang, Jian Wen, Wang   +4 more
openaire   +2 more sources

Glaucocalyxin A Attenuates the Activation of Hepatic Stellate Cells Through the TGF-β1/Smad Signaling Pathway

DNA and Cell Biology, 2018
Glaucocalyxin A (GLA) is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx. A large number of studies have shown that GLA possesses important pharmacological activities, such as anti-inflammatory, antitumor, antifibrosis, and antiplatelet activities.
Zhichao Dong, Qi Gao, Hao Guo
semanticscholar   +3 more sources

X-ray and DFT Study of Glaucocalyxin A Compound with Cytotoxic Activity

Chinese Journal of Chemical Physics, 2009
The title compound glaucocalyxin A (1) (7, 14-dihydroxy-ent-kaur-16-en-3,15-dione) isolated from the leaves of isodon excisoides was characterized by IR, 1H NMR, 13C NMR, 1H-1H COSY, HMQC, HMBC, and EIMS, and its crystal structure was determined by single-crystal X-ray diffraction. The X-ray crystal structure revealed that the molecular backbone of the
Wang, Fu-dong（Chinese Acad Sci, Lanzhou Inst Chem Phys）, Wang, Tao（ Xiamen Univ, Coll Phys & Mech Elect Engn）, Wu, An-an, Ding, Lan（NW Normal Univ, Coll Life Sci）, Wang, Han-qing（Chinese Acad Sci, Lanzhou Inst Chem Phys）   +4 more
openaire   +2 more sources

Controlled release of glaucocalyxin – a self-nanoemulsifying system from osmotic pump tablets with enhanced bioavailability

Pharmaceutical Development and Technology, 2017
The purpose of this study was to develop a new formulation to enhance the bioavailability simultaneously with controlled release of glaucocalyxin A (GLA).In this study, controlled release of GLA was achieved by the osmotic release strategy taking advantage of the bioavailability enhancing capacity of self-nanoemulsifying drug delivery systems (SNEDDS).
Yanfei Miao, Guoguang Chen, Ren Lili, Pingkai Ouyang   +3 more
semanticscholar   +3 more sources

Glaucocalyxin a prevents hypoxia-induced epithelial-mesenchymal transition in human gastric cancer cells through the PI3K/Akt signaling pathway

Journal of Receptor and Signal Transduction Research, 2020
Hypoxia is a frequent occurrence in most solid tumors and associated with multiple cancer progression. Glaucocalyxin A (GLA) has been found to exhibit anti-tumor effect in several types of cancer, except gastric cancer (GC).
Xi-han Zhou, Wei Ma, Xiaohui Li, Jia-li Xu   +3 more
semanticscholar   +1 more source