Results 121 to 130 of about 114,625,331 (143)
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Pharmacokinetic Analysis of Glaucocalyxin A in Rat Plasma by Liquid-Liquid Extraction and HPLC
Planta Medica, 2009A validated HPLC method is described for determination of glaucocalyxin A in rat plasma using liquid-liquid extraction and UV absorbance detection. The extraction recovery of glaucocalyxin A ranged from 81.72 % to 79.25 %, the linear range was 0.2-10 microg/mL, and R was 0.9984.
Luye, Cao +4 more
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Toxicology in Vitro, 2011
Glaucocalyxin A (GLA) is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx, a traditional Chinese medicinal herb, which has been shown to inhibit tumor cell proliferation. However, the mechanism underlying GLA-induced cytotoxicity remains unclear. In this study, we focused on the effect of GLA induction on
Jian Wen Wang
exaly +3 more sources
Glaucocalyxin A (GLA) is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx, a traditional Chinese medicinal herb, which has been shown to inhibit tumor cell proliferation. However, the mechanism underlying GLA-induced cytotoxicity remains unclear. In this study, we focused on the effect of GLA induction on
Jian Wen Wang
exaly +3 more sources
Pharmaceutical Development and Technology, 2015
The purpose of this study was to develop a new formulation to enhance the bioavailability simultaneously with controlled release of glaucocalyxin A (GLA).In this study, controlled release of GLA was achieved by the osmotic release strategy taking advantage of the bioavailability enhancing capacity of self-nanoemulsifying drug delivery systems (SNEDDS).
Miao, Yanfei +3 more
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The purpose of this study was to develop a new formulation to enhance the bioavailability simultaneously with controlled release of glaucocalyxin A (GLA).In this study, controlled release of GLA was achieved by the osmotic release strategy taking advantage of the bioavailability enhancing capacity of self-nanoemulsifying drug delivery systems (SNEDDS).
Miao, Yanfei +3 more
openaire +2 more sources
Biochemical and Biophysical Research Communications
Isodon japonicus (Nakai) Hara var. Japonicus (Japanese blue basil) has been widely used in traditional medicine to treat diarrhea. Glaucocalyxin A (Gla-A), one of its primary active constituents, has demonstrated anti-inflammatory, antitumor, antioxidant, and antifibrotic properties. Periodontitis, an inflammatory disease triggered by biofilm, leads to
Yuqi, Xin +7 more
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Isodon japonicus (Nakai) Hara var. Japonicus (Japanese blue basil) has been widely used in traditional medicine to treat diarrhea. Glaucocalyxin A (Gla-A), one of its primary active constituents, has demonstrated anti-inflammatory, antitumor, antioxidant, and antifibrotic properties. Periodontitis, an inflammatory disease triggered by biofilm, leads to
Yuqi, Xin +7 more
openaire +2 more sources
Journal of Plant Growth Regulation, 2013
Glaucocalyxin (Gla) A–C are major ent-kaurane diterpenoids isolated from Isodon japonicus var. glaucocalyx (Maxim.) H. W. Li. This study investigated the possible interference of these diterpenoids with root growth and its mechanism of action in lettuce (Lactuca sativa L.) seedlings.
Wen Hua Yang +3 more
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Glaucocalyxin (Gla) A–C are major ent-kaurane diterpenoids isolated from Isodon japonicus var. glaucocalyx (Maxim.) H. W. Li. This study investigated the possible interference of these diterpenoids with root growth and its mechanism of action in lettuce (Lactuca sativa L.) seedlings.
Wen Hua Yang +3 more
openaire +1 more source
New 3-acyl derivatives of glaucocalyxin A: designed, synthesis and in vitro antibacterial activities
Journal of Asian Natural Products ResearchTo discover novel antimicrobial drug, 22 novel acylated derivatives were synthesized by A-ring modification of glaucocalyxin A. The structures of these derivatives were confirmed by NMR and MS data. In vitro antimicrobial activity of these compounds was evaluated against E. faecium, E. faecalis, MRSA, E. coli, A. baumannii and K. pneumoniae.
Wei-Xian, Yang +5 more
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Bioorganic Chemistry
Glaucocalyxin A (GLA) is a bioactive diterpenoid isolated from Rabdosia japonica var. that has been applied for centuries in traditional Chinese medicine. Although GLA exhibits potent anticancer activity against various human cancer cells, its cellular targets remain largely unidentified.
Dongzhu, Duan +8 more
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Glaucocalyxin A (GLA) is a bioactive diterpenoid isolated from Rabdosia japonica var. that has been applied for centuries in traditional Chinese medicine. Although GLA exhibits potent anticancer activity against various human cancer cells, its cellular targets remain largely unidentified.
Dongzhu, Duan +8 more
openaire +2 more sources
[Effect of glaucocalyxin A on level of Th1/Th2 type cytokines in mice].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2007To research the effect of glaucocalyxin A (GLA) on the level of Th1/Th2 type cytokines in mice.By using flow cytometer with CBA software to detect Th1/Th2 type cytokines.GLA had insighificant inhibitory effects on Th1 and Th2 cytokines (IL-2, IFN-gamma,TNF-alpha, IL-4 and IL-5) induced by ConA, in which more potential on cytokines from Th1 than those ...
Zi-jun, Chen +3 more
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Effects of glaucocalyxin A on aggregation and cAMP levels of rabbit platelets in vitro.
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1993Glaucocalyxin A (Gla A) is a new diterpenoid isolated from ethereal extract of the leaves of Rabdosia japonica (Burm f) Hara var glaucocalyx (Maxim) Hara (Labiatae) collected in Northeastern China. When incubated with washed rabbit platelets, Gla A inhibited ADP-, AA-, and PAF-induced aggregation of rabbit platelets with IC50 values of 3.44, 13.32, and
B, Zhang, K, Long
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