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Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice

open access: yes, 2005
Wanrooij S   +8 more
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X-ray and DFT Study of Glaucocalyxin A Compound with Cytotoxic Activity

open access: yesChinese Journal of Chemical Physics, 2009
The title compound glaucocalyxin A (1) (7, 14-dihydroxy-ent-kaur-16-en-3,15-dione) isolated from the leaves of isodon excisoides was characterized by IR, 1H NMR, 13C NMR, 1H-1H COSY, HMQC, HMBC, and EIMS, and its crystal structure was determined by single-crystal X-ray diffraction. The X-ray crystal structure revealed that the molecular backbone of the
An-An Wu, Lan Ding
exaly   +4 more sources
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Glaucocalyxin A: a review

Natural Product Research, 2014
Glaucocalyxin A is a natural ent-Kaurane diterpenoid. It has been widely studied for some important biological activities like cytotoxicity and anti-tumour, anti-bacterial, anti-oxidative, anti-coagulative, anti-thrombotic, immune and anti-neuroinflammatory activities.
Yong-Sheng Jin
exaly   +3 more sources

Glycosylation of Glaucocalyxin a and Evaluation of Its Cytotoxic Activity

Chemistry of Natural Compounds, 2020
The 7,14-diglucoside of glaucocalyxin A was prepared by a five-step reaction. Its structure was confirmed by spectroscopic methods, and its cytotoxic activity was tested by the MTT method.
Yong-Sheng Jin
exaly   +2 more sources

Synthesis and Cytotoxic Activity of Hydroxy-Substituted Glaucocalyxin A

Pharmaceutical Chemistry Journal, 2019
Six new glaucocalyxin A derivatives were synthesized by hydroxy substitution, their structures were elucidated on the basis of spectral analysis, and cytotoxic activity was tested by MTT method. Not all of the obtained glaucocalyxin A derivatives have their cytotoxicity enhanced as a result of this substitution.
Xu-Xu Zheng
exaly   +2 more sources

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