Results 101 to 110 of about 151,452 (287)

Protein misfolding and mitochondrial dysfunction in glaucoma

Frontiers in Cell and Developmental Biology
Glaucoma is a leading cause of irreversible blindness worldwide. Elevated intraocular pressure caused by restricted outflow of the aqueous humor leads to the degeneration of retinal ganglion cells (RGCs) and their axons.
Arunkumar Venkatesan, Audrey M. Bernstein, Audrey M. Bernstein   +2 more
doaj   +1 more source

Risk of open angle glaucoma due to tumor necrosis factor alpha gene polymorphisms

Electronic Physician, 2016
Introduction: Axonal degeneration and retinal ganglion cell apoptosis in glaucoma is associated with tumor necrosis factor alpha (TNF-α), which is an important pro-inflammatory cytokine.
Mona Abdel Hamid, Leqaa Moemen, Hany Labib, Hazem Helmy, Tarek Elsergany   +4 more
doaj   +1 more source

Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degeneration

Scientific Reports, 2016
Primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD) are leading causes of irreversible blindness. Several loci have been mapped using genome-wide association studies.
G. Cuéllar-Partida, J. Craig, K. Burdon, Jie-Jin Wang, B. Vote, E. Souzeau, I. McAllister, T. Isaacs, Stewart R. Lake, D. Mackey, I. Constable, P. Mitchell, A. Hewitt, S. Macgregor   +13 more
semanticscholar   +1 more source

Validating Variational Bayes Linear Regression Method With Multi-Central Datasets. [PDF]

, 2018
PurposeTo validate the prediction accuracy of variational Bayes linear regression (VBLR) with two datasets external to the training dataset.MethodThe training dataset consisted of 7268 eyes of 4278 subjects from the University of Tokyo Hospital.
Asaoka, Ryo, Fujino, Yuri, Hirasawa, Kazunori, Kashiwagi, Kenji, Matsuura, Masato, Miki, Atsuya, Mizoue, Shiro, Mori, Kazuhiko, Murata, Hiroshi, Shoji, Nobuyuki, Suzuki, Katsuyoshi, Tanito, Masaki, Yamashita, Takehiro, Zangwill, Linda M   +13 more
core   +1 more source

Congenital aniridia: European COST action ANIRIDIA‐NET guidelines for diagnosis, management and care

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare ocular disorder affecting the majority of eye structures and can be associated with systemic manifestations. The main visible phenotypic characteristic is the partial or complete absence of the iris; however, foveal hypoplasia is a more frequent and reliable clinical sign. Other ocular comorbidities are associated
Davide Romano, Vito Romano, Alejandra Daruich, Giulio Ferrari, Matthieu Robert, Francesco Semeraro, Neil Lagali, Dominique Bremond‐Gignac, the ANIRIDIA‐NET Clinical Guidelines Working Group, Miriam Barbany, Claus Cursiefen, Stefano Ferrari, Francisco Figueiredo, Christina Grupcheva, Jesper Hjortdal, Elke Kreps, Erlend Landsend, Laura Mauring, Hilde Pedersen, Nora Szentmáry, Bogumil Wowra, the Aniridia‐Europa and Geniris Working Group, Sophie Valleix, Juan Álvarez de Toledo, James Lauderdale, Tor Paaske Utheim, Paolo Rama   +26 more
wiley   +1 more source

Efficacy and Adverse Event Profile of the iStent and iStent Inject Trabecular Micro-bypass for Open-angle Glaucoma: A Meta-analysis

Journal of current glaucoma practice, 2018
Aim This meta-analysis explores the efficacy and adverse event profile of the iStent, an ab interno implant for the treatment of open-angle glaucoma. Methods A systematic literature search of Ovid MEDLINE and EMBASE was used to identify peer-reviewed ...
M. Popovic, Xavier Campos-Moller, Hady Saheb, Iqbal Ike K Ahmed   +3 more
semanticscholar   +1 more source

Rates of macular volume changes in different stages and courses of primary open-angle glaucoma

Journal of Ophthalmology
Purpose: To examine macular volume changes as assessed by optical coherence tomography (OCT) and rates of these changes in different stages and courses of primary open-angle glaucoma (POAG).
M. V. Panchenko, O. M. Honchar, H. Yu. Panchenko, I. V. Kitchenko   +3 more
doaj   +1 more source

High interleukin-8 level in aqueous humor is associated with poor prognosis in eyes with open angle glaucoma and neovascular glaucoma

Scientific Reports, 2018
Glaucoma is a leading cause of blindness worldwide. Purpose of this study was to identify molecular markers that were significantly correlated with presence of glaucoma and outcome of glaucoma surgery.
Ikuyo Chono, D. Miyazaki, Hitomi Miyake, Naoki Komatsu, Fumie Ehara, Daisuke Nagase, Yukimi Kawamoto, Yumiko Shimizu, R. Ideta, Y. Inoue   +9 more
semanticscholar   +1 more source

Incidence, risk factors, and outcomes of numerical hypotony and choroidal effusion following PRESERFLO MicroShunt implantation

Acta Ophthalmologica, EarlyView.
Abstract Purpose To evaluate the incidence, outcomes, and risk factors of numerical hypotony (NH) and choroidal effusion (CE) following standalone PRESERFLO MicroShunt (PMS) implantation. Methods Primary open‐angle glaucoma (POAG) and pseudoexfoliative glaucoma (PXG) patients with uni‐ or bilateral surgery at a tertiary university hospital were ...
Emil Nasyrov, Isabel Kommerell, Isabell Schleicher, David A. Merle, Caroline J. Wenzel, Bogomil Voykov   +5 more
wiley   +1 more source

Epidemiological characterization of primary open-angle glaucoma

Medisur, 2010
Background: The primary open-angle glaucoma is a problem for public health all over the world. It is a silent and slowly progressive disease leading to blindness.
Leonor Rosario Díaz Alfonso, Bárbara Nuria Suárez Rodríguez, Mariela Julia Curbelo, Yusdenia Soto Serrano, Armando Rafael Milanés Armengol   +4 more
doaj   +2 more sources