Results 91 to 100 of about 470,158 (371)

Retinal Image Synthesis and Semi-Supervised Learning for Glaucoma Assessment

IEEE Transactions on Medical Imaging, 2019
Recent works show that generative adversarial networks (GANs) can be successfully applied to image synthesis and semi-supervised learning, where, given a small labeled database and a large unlabeled database, the goal is to train a powerful classifier ...
A. Diaz-Pinto, Adrián Colomer, V. Naranjo, Sandra Morales, Yanwu Xu, Alejandro F Frangi   +5 more
semanticscholar   +1 more source

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

Validation and reproducibility of the Heidelberg Edge Perimeter in the detection of glaucomatous visual field defects [PDF]

International Journal of Ophthalmology, 2019
AIM: To validate the ability of the Heidelberg Edge Perimeter (HEP) in detecting glaucomatous visual field (VF) defects compared to the Octopus Visual Field (OVF) Analyzer and to determine the test-retest repeatability of both modalities.
Qi N. Cui, Priyanka Gogt, Jonathan M. Lam, Safa Siraj, Lisa A. Hark, Jonathan S. Myers, L. Jay Katz, Michael Waisbourd   +7 more
doaj   +1 more source

Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always [PDF]

, 2017
Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs deputed to non-image forming functions of the eye such as synchronization of circadian rhythms to light-dark cycle.
Carelli, Valerio, Georg, Birgitte, Ghelli, Anna, Giordano, Carla, Hannibal, Jens, La Morgia, Chiara, Ross Cisneros, Fred N., Sadun, Alfredo A.   +7 more
core   +1 more source

Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma

Nature Communications, 2018
Glaucoma is the most prevalent neurodegenerative disease and a leading cause of blindness worldwide. The mechanisms causing glaucomatous neurodegeneration are not fully understood.
Ching-Hung Kaur, Mandeep Chen, Guochun Mathew, Lisa Fazelat, Ahad Lashkari, Ka-Nam Au, Ngan Pan, Bennett Tse, Joyce Ka, Yu Li, Yingqian Yu, Honghua Yang, Lanbo Stein-Streilein, Huihui Chen, Kin-Sang Cho, T. Vu, Ching-Hung Shen, Mandeep Kaur, Guochun Chen, R. Mathew, M. L. McHam, A. Fazelat, K. Lashkari, N. Au, Joyce K Y Tse, Yingqian Li, Honghua Yu, Lanbo Yang, J. Stein‐Streilein, C. H. Ma, C. Woolf, M. Whary, M. Jager, J. Fox, Jianzhu Chen, D. Chen   +35 more
semanticscholar   +1 more source

The Diagnosis and Treatment of Glaucoma.

Deutsches Ärzteblatt International, 2020
BACKGROUND Glaucoma is a group of chronically progressive disorders of the optic nerve. In this article, we present the epidemiology of and risk factors for glaucoma, as well as the diagnostic work-up and treatment options. METHODS This review is based
A. Schuster, C. Erb, E. Hoffmann, T. Dietlein, N. Pfeiffer   +4 more
semanticscholar   +1 more source

Metabolic Stress‐Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes‐Associated Microvascular Dysfunction

Advanced Science, EarlyView.
This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren, Linyu Zhang, Yun Bai, Chang Huang, Xiaosa Li, Fanfei Ma, Wan Mu, Mudi Yao, Chang Jiang, Xiangjun Chen, Qin Jiang, Biao Yan   +11 more
wiley   +1 more source

Contemporary Approach to Narrow Angles

Journal of Ophthalmic & Vision Research
Glaucoma is the leading cause of irreversible blindness worldwide. Among all glaucoma types, primary angle closure glaucoma (PACG) affects approximately 23 million people worldwide, and is responsible for 50% of glaucoma-related blindness, highlighting ...
Wesam Shamseldin Shalaby, Rohit Reddy, Reza Razeghinejad, L. Jay Katz   +3 more
doaj   +1 more source

Construction of miRNA-mRNA regulatory network indicates potential biomarkers for primary open-angle glaucoma

BMC Medical Genomics, 2023
Background Trabecular meshwork (TM) dysfunction-induced elevation of intraocular pressure has been identified as the main risk factor of irreversible optic nerve injury in Primary open‑angle glaucoma (POAG).
Xiaoyu Zhou, Feng Zhang, Xinyue Zhang, Dengming Zhou, Yang Zhao, Baihua Chen, Xuanchu Duan   +6 more
doaj   +1 more source

Current Medical Therapy and Future Trends in the Management of Glaucoma Treatment

Journal of Ophthalmology, 2020
Glaucoma is a neurodegenerative disease characterized by progressive loss of retinal ganglion cells and their axons. Lowering of intraocular pressure (IOP) is currently the only proven treatment strategy for glaucoma.
B. Cvenkel, M. Kolko
semanticscholar   +1 more source